Anaplastic/large cell medulloblastoma is a rare and aggressive type of brain tumor that affects the cerebellum, which is the part of the brain responsible for controlling movement and coordination. It is a malignant tumor that is composed of large, anaplastic cells. It is most commonly found in children and adolescents, and is usually treated with surgery, radiation, and chemotherapy.

The most common symptoms of anaplastic/large cell medulloblastoma include:

-Headaches
-Nausea and vomiting
-Balance and coordination problems
-Changes in vision
-Hearing loss
-Weakness or Paralysis on one side of the body
-Seizures
-Personality changes
-Behavioral changes
-Difficulty speaking or understanding language
-Difficulty swallowing

The exact cause of anaplastic/large cell medulloblastoma is unknown. However, research suggests that genetic mutations may play a role in the development of this type of tumor. Additionally, environmental factors, such as exposure to radiation or certain chemicals, may increase the risk of developing this type of tumor.

The treatments for Anaplastic/large cell medulloblastoma typically include surgery, radiation therapy, and chemotherapy. Surgery is usually the first step in treatment and is used to remove as much of the tumor as possible. Radiation therapy is then used to target any remaining cancer cells. Chemotherapy is often used in combination with radiation therapy to help kill any remaining cancer cells. In some cases, targeted therapies such as immunotherapy may also be used.

1. Age: Anaplastic/large cell medulloblastoma is most commonly seen in children between the ages of 5 and 10.

2. Gender: Boys are more likely to develop this type of tumor than girls.

3. Genetics: Certain genetic mutations, such as those in the PTEN gene, have been linked to an increased risk of developing this type of tumor.

4. Exposure to radiation: Exposure to radiation, either through medical treatments or environmental sources, may increase the risk of developing this type of tumor.

5. Family history: Having a family history of brain tumors may increase the risk of developing this type of tumor.

Unfortunately, there is no cure for anaplastic/large cell medulloblastoma. Treatment typically involves a combination of surgery, radiation therapy, and chemotherapy. Depending on the individual case, medications such as temozolomide, vincristine, and cisplatin may be used.