Aminopterin/methotrexate embryofetopathy is a rare birth defect caused by the use of the drugs aminopterin or methotrexate during pregnancy. These drugs are used to treat certain types of cancer, autoimmune diseases, and other conditions. When taken during pregnancy, they can cause severe birth defects, including heart defects, facial malformations, and central nervous system abnormalities.

The symptoms of Aminopterin/methotrexate embryofetopathy vary depending on the severity of the condition, but may include:

-Growth retardation

-Developmental delay

-Craniofacial abnormalities

-Cleft lip and/or palate

-Cardiac defects

-CNS abnormalities

-Genitourinary anomalies

-Skeletal abnormalities

-Hearing loss

-Vision problems

-Feeding difficulties

-Respiratory problems

-Neurological problems

-Behavioral problems

-Immune system problems

Aminopterin/methotrexate embryofetopathy is a rare birth defect caused by the use of the drugs aminopterin or methotrexate during pregnancy. These drugs are used to treat certain types of cancer, autoimmune diseases, and other conditions. When taken during pregnancy, they can cause severe birth defects in the developing fetus. The exact cause of the birth defects is unknown, but it is believed to be related to the drugs’ ability to interfere with the normal development of the fetus.

The primary treatment for Aminopterin/methotrexate embryofetopathy is supportive care. This includes monitoring the baby's growth and development, providing nutrition and hydration, and providing physical and occupational therapy as needed. In some cases, surgery may be necessary to correct any physical abnormalities. In addition, medications may be prescribed to help manage any associated medical conditions.

1. Maternal use of aminopterin/methotrexate during pregnancy
2. High doses of aminopterin/methotrexate
3. Long-term use of aminopterin/methotrexate
4. Maternal age over 35
5. Maternal obesity
6. Maternal diabetes
7. Maternal hypertension
8. Maternal smoking
9. Maternal alcohol use
10. Maternal use of other medications during pregnancy

There is no known cure for Aminopterin/methotrexate embryofetopathy. However, supportive care and monitoring of the affected individual can help to improve their quality of life. Medications such as folic acid, vitamin B12, and other vitamins and minerals may be prescribed to help reduce the risk of complications. Additionally, physical and occupational therapy may be recommended to help improve the individual's physical and cognitive abilities.