5-Fluorouracil (5-FU) poisoning is a type of poisoning caused by an overdose of the chemotherapy drug 5-fluorouracil. Symptoms of 5-FU poisoning can include nausea, vomiting, abdominal pain, confusion, and seizures. In severe cases, 5-FU poisoning can lead to coma and death. Treatment for 5-FU poisoning typically involves supportive care and the administration of medications to reduce the effects of the drug.

Symptoms of 5-fluorouracil poisoning may include:

-Nausea and vomiting
-Diarrhea
-Abdominal pain
-Fatigue
-Loss of appetite
-Fever
-Rash
-Hair loss
-Mouth sores
-Confusion
-Dizziness
-Weakness
-Headache
-Shortness of breath
-Low blood pressure
-Seizures
-Coma

1. Overdose of 5-fluorouracil: Taking too much 5-fluorouracil can lead to poisoning.

2. Accidental ingestion: Ingesting 5-fluorouracil accidentally can lead to poisoning.

3. Contamination: Contamination of 5-fluorouracil with other drugs or chemicals can lead to poisoning.

4. Interaction with other drugs: Taking 5-fluorouracil with other drugs can lead to poisoning.

5. Allergic reaction: An allergic reaction to 5-fluorouracil can lead to poisoning.

1. Activated charcoal: This is used to absorb any remaining 5-fluorouracil in the stomach and intestines.

2. Intravenous fluids: This is used to flush out the 5-fluorouracil from the body.

3. Dialysis: This is used to remove 5-fluorouracil from the blood.

4. Antidotes: There are several antidotes available for 5-fluorouracil poisoning, including leucovorin, mesna, and amifostine.

5. Supportive care: This includes monitoring vital signs, providing oxygen, and administering medications to treat symptoms such as nausea and vomiting.

1. High doses of 5-fluorouracil
2. Prolonged use of 5-fluorouracil
3. Impaired kidney or liver function
4. Use of other medications that interact with 5-fluorouracil
5. Advanced age
6. Poor nutrition
7. Alcohol use
8. Dehydration

There is no specific antidote for 5-fluorouracil poisoning. Treatment is supportive and may include intravenous fluids, electrolyte replacement, and medications to reduce nausea and vomiting. In severe cases, hemodialysis may be necessary to remove the drug from the body.