Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome (SJS/TEN) is a rare and potentially life-threatening skin disorder. It is a severe reaction to certain medications or infections that causes the skin to blister and peel off. It is a combination of two conditions: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). SJS is a less severe form of the disorder, while TEN is more severe. Symptoms of SJS/TEN overlap syndrome include fever, rash, skin lesions, and blisters on the skin and mucous membranes. In severe cases, the skin may slough off in sheets, leaving the patient at risk for infection and dehydration. Treatment typically involves discontinuing the medication or infection that caused the reaction, as well as supportive care.

The symptoms of Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome include:

-Fever
-Fatigue
-Sore throat
-Cough
-Red or purplish rash that spreads and blisters
-Shedding of the top layer of the skin
-Eye Irritation and redness
-Mouth sores
-Swollen lymph nodes
-Joint pain
-Difficulty breathing
-Nausea and vomiting
-Diarrhea
-Abdominal pain
-Loss of appetite
-Dehydration

The exact cause of Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome (SJS/TEN) is unknown. However, it is believed to be triggered by certain medications, infections, or other medical conditions. Common triggers include:

• Certain medications, such as antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, and sulfonamides

• Infections, such as herpes simplex virus, HIV, and Mycoplasma pneumoniae

• Other medical conditions, such as lupus, cancer, and HIV/AIDS

• Exposure to certain chemicals, such as formaldehyde and phenol

The treatment for Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome (SJS/TEN) is primarily supportive care. This includes:

1. Discontinuing the medication that is thought to be causing the reaction.

2. Treating any underlying infections.

3. Providing fluids and nutrition to prevent dehydration and malnutrition.

4. Treating any pain or discomfort with medications.

5. Treating any eye problems with lubricating eye drops or ointments.

6. Treating any skin problems with topical creams or ointments.

7. Treating any respiratory problems with oxygen therapy.

8. Treating any secondary infections with antibiotics.

9. Treating any organ damage with medications or surgery.

10. Providing psychological

1. Certain medications, including antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, and sulfonamides.

2. Infections, such as HIV, herpes simplex virus, and Mycoplasma pneumonia.

3. Allergies to certain medications, foods, or other substances.

4. Genetic predisposition.

5. Age (children and elderly are more likely to develop SJS/TEN).

6. Immunosuppression due to certain medical conditions or treatments.

7. Exposure to certain chemicals or environmental toxins.

Yes, there are treatments available for Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome. Treatment typically involves supportive care, such as fluids and nutrition, and medications to reduce inflammation and pain. Other medications may be used to treat any underlying infections or other medical conditions. In some cases, a skin graft may be necessary to repair damaged skin.