Median cleft lip/mandibule is a rare congenital deformity in which the upper lip and the mandible (lower jaw) are split in the middle. It is caused by a failure of the two sides of the face to fuse together during fetal development. This can cause a wide range of facial deformities, including a cleft lip, cleft palate, and/or a cleft chin. Treatment for this condition typically involves reconstructive surgery to repair the deformity.

The most common symptoms of median cleft lip/mandibule include:

-A deep groove or cleft in the middle of the upper lip
-A wide gap between the two sides of the upper lip
-A wide gap between the two sides of the lower jaw
-A wide gap between the two sides of the nose
-A wide gap between the two sides of the chin
-A wide gap between the two sides of the forehead
-A wide gap between the two sides of the cheeks
-A wide gap between the two sides of the eyelids
-A wide gap between the two sides of the ears
-A wide gap between the two sides of the neck
-A wide gap between the two sides of the mouth
-A wide gap between the two sides of the tongue
-A wide gap between the two

Median cleft lip/mandibule is a rare congenital malformation that is caused by a combination of genetic and environmental factors. Genetic factors include mutations in the genes that control facial development, such as the PAX3 gene. Environmental factors include exposure to certain medications, alcohol, or drugs during pregnancy, as well as maternal malnutrition.

1. Surgery: Surgery is the most common treatment for median cleft lip/mandibule. The goal of surgery is to close the cleft and restore normal facial appearance and function.

2. Orthodontic Treatment: Orthodontic treatment may be necessary to correct any misalignment of the teeth and jaw.

3. Speech Therapy: Speech therapy may be necessary to help the patient learn to speak clearly and correctly.

4. Psychological Support: Psychological support may be necessary to help the patient cope with the physical and emotional effects of the condition.

5. Nutrition: A balanced diet is important to ensure proper growth and development.

1. Genetic factors: A family history of median cleft lip/mandibular is a risk factor for the condition.

2. Environmental factors: Exposure to certain environmental toxins, such as alcohol, drugs, and tobacco, during pregnancy can increase the risk of median cleft lip/mandibular.

3. Maternal health: Certain maternal health conditions, such as diabetes, obesity, and hypertension, can increase the risk of median cleft lip/mandibular.

4. Medications: Taking certain medications, such as anticonvulsants, during pregnancy can increase the risk of median cleft lip/mandibular.

5. Ethnicity: Certain ethnic groups, such as Native Americans and Hispanics, are at an increased risk of median cleft lip/mandibular.

Yes, there are treatments available for median cleft lip/mandibule. Treatment typically involves a combination of surgery and orthodontic treatment. Surgery is used to close the cleft and reshape the lip and/or mandible. Orthodontic treatment is used to align the teeth and jaw. In some cases, speech therapy may also be recommended.