Zinc-responsive necrolytic acral erythema (ZRAE) is a rare skin condition characterized by red, scaly, and painful patches on the palms and soles of the feet. It is caused by a deficiency of zinc in the body, which can be caused by a variety of factors, including malnutrition, malabsorption, and certain medications. Treatment typically involves supplementing with zinc and other vitamins and minerals, as well as topical treatments to reduce inflammation and itching.

The symptoms of Zinc-responsive necrolytic acral erythema include:

-Red, scaly, and itchy patches of skin on the hands, feet, and ankles
-Painful Blisters or ulcers on the affected areas
-Thickening and discoloration of the skin
-Cracking and peeling of the skin
-Swelling and tenderness of the affected areas
-Fever
-Fatigue
-Weight loss
-Loss of appetite
-Nausea
-Vomiting
-Diarrhea

The exact cause of zinc-responsive necrolytic acral erythema is unknown, but it is believed to be related to a deficiency in zinc. Other possible causes include genetic factors, autoimmune disorders, and certain medications.

1. Topical corticosteroids: These are used to reduce inflammation and itching.

2. Oral zinc supplementation: This is the main treatment for zinc-responsive necrolytic acral erythema. It is important to take the correct dosage of zinc as too much can be toxic.

3. Phototherapy: This involves exposing the affected area to ultraviolet light.

4. Antihistamines: These can be used to reduce itching and inflammation.

5. Antibiotics: These may be prescribed if there is an infection present.

6. Moisturizers: These can help to reduce dryness and irritation.

7. Oral retinoids: These can be used to reduce inflammation and improve skin texture.

1. Diabetes mellitus
2. Alcoholism
3. Liver disease
4. Malnutrition
5. Medications such as penicillamine, captopril, and cimetidine
6. Genetic predisposition
7. Immunosuppression
8. HIV infection

At this time, there is no known cure for zinc-responsive necrolytic acral erythema. However, medications such as topical corticosteroids, oral antibiotics, and oral zinc supplements may be used to help manage the symptoms. Additionally, lifestyle changes such as avoiding triggers, using moisturizers, and protecting the skin from the sun may also help.