X-linked spastic paraplegia type 34 (SPG34) is a rare, inherited neurological disorder that affects the movement of the legs. It is caused by mutations in the SPG34 gene, which is located on the X chromosome. Symptoms of SPG34 include spasticity (stiffness and difficulty with movement) of the legs, difficulty walking, and intellectual disability. The severity of the symptoms can vary from person to person.

The symptoms of X-linked spastic paraplegia type 34 (SPG34) vary from person to person, but may include:

- Muscle Stiffness and Spasticity in the legs

- Weakness in the legs

- Difficulty walking
- Abnormal gait
- Loss of balance
- Difficulty climbing stairs
- Difficulty rising from a seated position
- Urinary incontinence
- Constipation
- Pain in the legs
- Fatigue
- Speech difficulties
- Cognitive impairment

X-linked spastic paraplegia type 34 (SPG34) is caused by mutations in the gene SPG34, which is located on the X chromosome. Mutations in this gene lead to a decrease in the production of a protein called spastin, which is involved in the maintenance of the structure and function of nerve cells. This decrease in spastin production leads to the development of spastic paraplegia, which is characterized by progressive muscle stiffness and weakness in the legs.

1. Being male: X-linked spastic paraplegia type 34 is caused by a mutation in the SPG34 gene, which is located on the X chromosome. As males only have one X chromosome, they are more likely to be affected by this condition than females.

2. Family history: X-linked spastic paraplegia type 34 is inherited in an X-linked recessive pattern, which means that it is passed down from a parent who carries the mutated gene. If a family member has the condition, then other family members may be at an increased risk of developing it.

3. Age: X-linked spastic paraplegia type 34 usually begins in childhood or adolescence, although it can also occur in adulthood.

At this time, there is no known cure or medications for X-linked spastic paraplegia type 34. Treatment is focused on managing the symptoms and improving quality of life. This may include physical therapy, occupational therapy, speech therapy, and medications to help manage muscle spasms and pain.