White-Sutton syndrome is a rare genetic disorder characterized by intellectual disability, delayed development, and distinctive facial features. It is caused by a mutation in the ZBTB20 gene. Symptoms may include low muscle tone, seizures, hearing loss, and vision problems.

The most common symptoms of White-Sutton syndrome include:

-Developmental delay
-Intellectual disability
-Seizures
-Feeding difficulties
-Growth delays
-Hearing loss
-Vision problems
-Heart defects
-Kidney abnormalities
-Cleft lip and/or palate
-Abnormalities of the hands and feet
-Behavioral problems
-Speech delays

White-Sutton Syndrome is a rare genetic disorder caused by a mutation in the PEX1 gene. This gene is responsible for the production of an enzyme called peroxisomal biogenesis factor 1 (PBF-1). This enzyme is essential for the proper functioning of peroxisomes, which are small organelles found in cells that are involved in many important metabolic processes. Mutations in the PEX1 gene can lead to a decrease in the amount of PBF-1 enzyme produced, resulting in White-Sutton Syndrome.

The treatment for White-Sutton syndrome is focused on managing the symptoms. This may include physical therapy, occupational therapy, speech therapy, and medications to help with muscle spasms, seizures, and other symptoms. Surgery may be recommended to correct any physical deformities or to help with mobility. In some cases, genetic counseling may be recommended to help families understand the condition and its implications.

The primary risk factor for White-Sutton syndrome is having a parent with the condition. Other risk factors include having a family history of the disorder, being of Ashkenazi Jewish descent, and having a genetic mutation in the SLC9A6 gene.

There is no cure for White-Sutton syndrome. Treatment focuses on managing the symptoms and complications associated with the condition. Medications may be prescribed to help manage seizures, muscle spasms, and other symptoms. Physical and occupational therapy may also be recommended to help improve mobility and coordination.