WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome is a rare genetic disorder characterized by facial dysmorphism, developmental delay, and behavioral abnormalities. It is caused by a mutation in the WAC gene, which is responsible for the production of a protein involved in the regulation of cell growth and development. Symptoms of this disorder include facial features such as a broad forehead, wide-set eyes, and a short nose, as well as developmental delays, intellectual disability, and behavioral problems such as hyperactivity and impulsivity. Treatment for this disorder is supportive and may include physical, occupational, and speech therapy, as well as medications to help manage behavioral symptoms.

The symptoms of WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome include:

• Facial dysmorphism: A distinctive facial appearance, including a broad forehead, wide-set eyes, a flat nasal bridge, and a wide mouth.

• Developmental delay: Delays in reaching developmental milestones, such as walking, talking, and toilet training.

• Behavioral abnormalities: Hyperactivity, impulsivity, aggression, and difficulty with social interactions.

• Intellectual disability: A lower than average IQ.

• Seizures: Epileptic Seizures may occur in some cases.

• Feeding difficulties: Difficulty with feeding, including difficulty swallowing and poor appetite.

The exact cause of WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome is unknown. However, it is believed to be caused by a genetic mutation in the WAC gene, which is located on chromosome 17. This gene is responsible for the production of a protein called WAC, which is involved in the development of the nervous system. Mutations in this gene can lead to the facial dysmorphism, developmental delay, and behavioral abnormalities seen in this syndrome.

Treatment for WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome is typically focused on managing the individual symptoms. This may include physical therapy to help with motor development, speech therapy to help with communication, occupational therapy to help with daily activities, and behavioral therapy to help with any behavioral issues. Medications may also be prescribed to help with any anxiety or depression. Additionally, genetic counseling may be recommended to help families understand the condition and its implications.

1. Maternal exposure to certain medications during pregnancy, such as anticonvulsants, anti-depressants, and anti-psychotics.

2. Maternal exposure to environmental toxins, such as lead, mercury, and polychlorinated biphenyls (PCBs).

3. Maternal alcohol or drug use during pregnancy.

4. Maternal smoking during pregnancy.

5. Maternal nutritional deficiencies during pregnancy.

6. Maternal infections during pregnancy, such as rubella, cytomegalovirus, and toxoplasmosis.

7. Genetic factors, such as chromosomal abnormalities or mutations in certain genes.

At this time, there is no known cure for WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome. However, there are medications that can be used to help manage the symptoms associated with this syndrome. These medications may include antipsychotics, antidepressants, anticonvulsants, and stimulants. Additionally, behavioral therapy and other forms of psychotherapy may be beneficial in helping to manage the behavioral abnormalities associated with this syndrome.