About Twin-Twin Transfusion Syndrome

What is Twin-Twin Transfusion Syndrome?

Twin-Twin Transfusion Syndrome (TTTS) is a rare condition that affects identical twins who share a placenta. It occurs when the blood vessels in the placenta connecting the twins become unbalanced, allowing one twin to receive too much blood and the other too little. This can lead to serious health complications for both twins, including heart failure, anemia, and even death. Treatment options include laser ablation, amnioreduction, and fetoscopic surgery.

What are the symptoms of Twin-Twin Transfusion Syndrome?

The most common symptoms of Twin-Twin Transfusion Syndrome (TTTS) include:

- Unequal growth of the twins
- Excess amniotic fluid in one sac and very little in the other
- Abnormal blood flow between the twins
- Abnormal heart rate in one or both twins
- Abnormal development of one or both twins
- Premature birth
- Low birth weight
- Fetal death

What are the causes of Twin-Twin Transfusion Syndrome?

Twin-Twin Transfusion Syndrome (TTTS) is caused by an abnormal connection between the umbilical cords of identical twins that share a placenta. This connection, known as a vascular anastomosis, allows blood to flow between the twins, resulting in an unequal distribution of blood and nutrients. This can lead to a variety of complications, including preterm labor, birth defects, and even death.

What are the treatments for Twin-Twin Transfusion Syndrome?

The primary treatment for Twin-Twin Transfusion Syndrome (TTTS) is a procedure called fetoscopic laser ablation. This procedure involves using a laser to seal off the blood vessels that are connecting the twins and causing the TTTS. Other treatments may include amnioreduction (removal of excess amniotic fluid) or septostomy (creating a hole in the dividing membrane between the twins). In some cases, a combination of these treatments may be used.

What are the risk factors for Twin-Twin Transfusion Syndrome?

1. Monochorionic placenta: Twins who share a placenta are at higher risk for TTTS.

2. Unequal placental sharing: Unequal sharing of the placenta can lead to an imbalance in the blood flow between the twins.

3. Maternal age: Women over the age of 35 are at higher risk for TTTS.

4. Maternal diabetes: Women with diabetes are at higher risk for TTTS.

5. Maternal obesity: Women who are obese are at higher risk for TTTS.

6. Previous pregnancies: Women who have had multiple pregnancies are at higher risk for TTTS.

Is there a cure/medications for Twin-Twin Transfusion Syndrome?

Yes, there are treatments available for Twin-Twin Transfusion Syndrome. These treatments include laser ablation, amnioreduction, and fetoscopic laser ablation. Medications such as indomethacin and sildenafil may also be used to help reduce the risk of complications.