Transgrediens et progrediens palmoplantar keratoderma is a rare genetic disorder characterized by thickening of the skin on the palms and soles of the feet. It is caused by a mutation in the GJB2 gene, which is responsible for the production of a protein called connexin 26. Symptoms of this disorder include thickening of the skin on the palms and soles, painful fissures, and calluses. In some cases, the thickening of the skin can spread to other areas of the body. Treatment typically involves the use of topical medications and moisturizers to reduce the symptoms.

The symptoms of Transgrediens et progrediens palmoplantar keratoderma include thickening of the skin on the palms and soles, which can lead to painful cracking and fissuring. Other symptoms may include itching, burning, and Pain in the affected areas. In some cases, the skin may become red and inflamed.

Transgrediens et progrediens palmoplantar keratoderma (TPPK) is a rare genetic disorder that affects the skin on the palms and soles of the feet. The exact cause of TPPK is unknown, but it is believed to be caused by a combination of genetic and environmental factors. Genetic factors may include mutations in the GJB2 gene, which is responsible for the production of a protein called connexin 26. Environmental factors may include exposure to certain chemicals, such as formaldehyde, or to certain medications, such as anticonvulsants.

1. Topical treatments: These include topical retinoids, topical corticosteroids, topical calcipotriol, topical tacrolimus, and topical salicylic acid.

2. Systemic treatments: These include oral retinoids, oral acitretin, oral isotretinoin, oral cyclosporine, and oral methotrexate.

3. Phototherapy: This includes narrowband ultraviolet B (UVB) and psoralen plus ultraviolet A (PUVA) therapy.

4. Surgery: This includes dermabrasion, curettage, and laser ablation.

1. Genetic predisposition: Transgrediens et progrediens palmoplantar keratoderma is an inherited condition, and it is believed to be caused by a mutation in the GJB2 gene.

2. Environmental factors: Exposure to certain chemicals, such as solvents, can increase the risk of developing this condition.

3. Age: Transgrediens et progrediens palmoplantar keratoderma is more common in adults than in children.

4. Gender: This condition is more common in males than in females.

5. Ethnicity: This condition is more common in people of Mediterranean descent.

There is no known cure for transgrediens et progrediens palmoplantar keratoderma. However, there are medications that can help to reduce the symptoms and slow the progression of the condition. These include topical retinoids, topical corticosteroids, and oral retinoids. Additionally, moisturizing creams and emollients can help to reduce the dryness and cracking of the skin.