Temple syndrome is a rare genetic disorder caused by a mutation in the paternal 14q32.2 region of the genome. This mutation results in hypomethylation, which is a decrease in the amount of methylation of the DNA in that region. This hypomethylation can lead to a variety of physical and neurological symptoms, including intellectual disability, seizures, and autism spectrum disorder.

The symptoms of Temple syndrome due to paternal 14q32.2 hypomethylation can vary from person to person, but may include:

-Developmental delay
-Intellectual disability
-Seizures
-Growth retardation
-Feeding difficulties
-Speech and language delays
-Behavioral problems
-Abnormal facial features
-Hearing loss
-Vision problems
-Heart defects
-Kidney abnormalities
-Gastrointestinal issues
-Skeletal abnormalities

The exact cause of Temple syndrome due to paternal 14q32.2 hypomethylation is unknown. However, it is believed to be caused by a genetic mutation that affects the methylation of the 14q32.2 region of the father's DNA. This mutation results in the abnormal expression of certain genes in the affected individual, leading to the development of Temple syndrome.

Treatment for Temple syndrome due to paternal 14q32.2 hypomethylation is largely supportive and symptomatic. Treatment may include physical therapy, occupational therapy, speech therapy, and medications to help manage symptoms such as seizures, muscle spasms, and behavioral issues. In some cases, surgery may be recommended to correct physical abnormalities. Genetic counseling may also be recommended to help families understand the condition and its implications.

1. Advanced paternal age
2. Uniparental disomy (UPD)
3. Maternal duplication of 14q32.2
4. Maternal uniparental disomy (UPD) of 14q32.2
5. Maternal imprinting defects
6. Maternal genetic variants in the 14q32.2 region
7. Paternal genetic variants in the 14q32.2 region
8. Maternal exposure to environmental toxins
9. Paternal exposure to environmental toxins
10. Maternal exposure to radiation
11. Paternal exposure to radiation
12. Maternal use of assisted reproductive technologies
13. Paternal use of assisted reproductive technologies
14. Maternal advanced maternal age

At this time, there is no known cure or medications for Temple syndrome due to paternal 14q32.2 hypomethylation. Treatment is focused on managing the symptoms of the condition, which can include physical therapy, occupational therapy, speech therapy, and medications to help with seizures, sleep, and behavior. Genetic counseling may also be recommended to help families understand the condition and its implications.