Temple syndrome due to maternal uniparental disomy of chromosome 14 is a rare genetic disorder caused by the presence of two copies of chromosome 14 from the mother instead of one from each parent. It is characterized by a variety of physical and developmental abnormalities, including facial dysmorphism, short stature, intellectual disability, and seizures.

The symptoms of Temple syndrome due to maternal uniparental disomy of chromosome 14 can vary, but may include:

-Developmental delay
-Intellectual disability
-Seizures
-Growth retardation
-Feeding difficulties
-Speech delay
-Behavioral problems
-Abnormal facial features
-Hearing loss
-Heart defects
-Kidney abnormalities
-Gastrointestinal problems
-Skeletal abnormalities
-Hypotonia (low muscle tone)
-Hypoglycemia (low blood sugar)

1. Maternal uniparental disomy (UPD) of chromosome 14 is a rare genetic disorder in which a person has two copies of chromosome 14 from their mother and none from their father.

2. This can occur due to a chromosomal abnormality in the mother's egg or sperm, or due to a chromosomal abnormality in the fertilized egg.

3. Temple syndrome is a rare genetic disorder caused by maternal UPD of chromosome 14. It is characterized by a variety of physical and neurological abnormalities, including facial dysmorphism, developmental delay, intellectual disability, seizures, and movement disorders.

4. The exact cause of Temple syndrome is unknown, but it is believed to be due to a combination of genetic and environmental factors.

Treatment for Temple syndrome due to maternal uniparental disomy of chromosome 14 is largely supportive and symptomatic. Treatment may include physical therapy, occupational therapy, speech therapy, and other therapies to help manage the physical and cognitive impairments associated with the condition. In some cases, medications may be prescribed to help manage seizures, sleep disturbances, and other symptoms. Genetic counseling may also be recommended to help families understand the condition and its implications.

1. Maternal uniparental disomy of chromosome 14
2. Advanced maternal age
3. Maternal diabetes
4. Maternal obesity
5. Maternal smoking
6. Maternal alcohol consumption
7. Maternal use of certain medications
8. Maternal exposure to environmental toxins
9. Genetic predisposition
10. Family history of Temple syndrome

At this time, there is no known cure for Temple syndrome due to maternal uniparental disomy of chromosome 14. Treatment focuses on managing the symptoms, which may include physical therapy, occupational therapy, speech therapy, and medications to help with seizures, muscle spasms, and other symptoms.