Systemic polyarteritis nodosa (PAN) is a rare autoimmune disorder that causes inflammation of the arteries throughout the body. It is a type of vasculitis, which is a group of disorders that cause inflammation of the blood vessels. Symptoms of PAN can include fever, fatigue, weight loss, joint pain, and abdominal pain. In some cases, it can also cause kidney failure, stroke, and heart attack. Treatment for PAN typically involves medications to reduce inflammation and suppress the immune system.

The symptoms of systemic polyarteritis nodosa (PAN) vary depending on the organs affected, but may include:

-Fever

-Fatigue

-Weight loss

-Muscle and joint pain

-Abdominal pain
-Nausea and vomiting
-Skin rash
-High blood pressure
-Kidney problems
-Liver problems
-Peripheral neuropathy (nerve damage)
-Raynaud's phenomenon (cold hands and feet)
-Gastrointestinal bleeding
-Blood clots
-Heart problems
-Breathing problems

The exact cause of systemic polyarteritis nodosa (PAN) is unknown. It is believed to be an autoimmune disorder, meaning the body's immune system mistakenly attacks healthy tissue. Possible triggers for PAN include infections, certain medications, and environmental factors.

The main treatments for Systemic polyarteritis nodosa (PAN) are corticosteroids and immunosuppressive medications. Corticosteroids, such as prednisone, are used to reduce inflammation and suppress the immune system. Immunosuppressive medications, such as cyclophosphamide, azathioprine, and methotrexate, are used to further suppress the immune system and reduce inflammation. In some cases, plasmapheresis (a procedure that removes antibodies from the blood) may be used to reduce inflammation. In severe cases, surgery may be necessary to repair damaged blood vessels.

1. Age: Systemic polyarteritis nodosa (PAN) is most common in people between the ages of 40 and 60.

2. Gender: PAN is more common in men than in women.

3. Ethnicity: PAN is more common in people of Asian descent.

4. Smoking: Smoking is a risk factor for PAN.

5. Infections: Certain infections, such as hepatitis B and C, may increase the risk of PAN.

6. Medications: Certain medications, such as certain antibiotics and nonsteroidal anti-inflammatory drugs, may increase the risk of PAN.

Yes, there are treatments available for Systemic polyarteritis nodosa. Treatment typically involves medications such as corticosteroids, immunosuppressants, and biologics. In some cases, surgery may be necessary to repair damaged blood vessels.