Systemic-onset juvenile idiopathic arthritis (JIA) is a type of juvenile idiopathic arthritis (JIA) that affects the entire body. It is characterized by inflammation of the joints, fever, rash, and enlargement of the lymph nodes, spleen, and liver. It is the most severe form of JIA and can cause serious complications if left untreated. Treatment typically involves medications to reduce inflammation and suppress the immune system.

The most common symptoms of systemic-onset juvenile idiopathic Arthritis (JIA) include:

-Fever
-Rash
-Enlarged lymph nodes
-Joint Pain and swelling
-Fatigue
-Weight loss
-Abdominal pain
-Eye Inflammation (uveitis)
-Anemia

The exact cause of systemic-onset juvenile idiopathic arthritis (JIA) is unknown. However, it is believed to be an autoimmune disorder, meaning that the body's immune system mistakenly attacks healthy cells and tissues. Possible triggers for this autoimmune response include genetic factors, environmental factors, and infections.

1. Nonsteroidal anti-inflammatory drugs (NSAIDs): These medications help reduce inflammation and pain.

2. Corticosteroids: These medications help reduce inflammation and suppress the immune system.

3. Disease-modifying antirheumatic drugs (DMARDs): These medications help slow down the progression of the disease and reduce inflammation.

4. Biologic agents: These medications target specific parts of the immune system to reduce inflammation.

5. Physical therapy: This helps maintain joint mobility and strength.

6. Occupational therapy: This helps maintain joint function and independence.

7. Surgery: This may be necessary to correct joint deformities or to replace a joint.

1. Age: Systemic-onset juvenile idiopathic arthritis typically affects children between the ages of 6 months and 16 years.

2. Gender: Girls are more likely to be affected than boys.

3. Family history: Having a family member with juvenile idiopathic arthritis increases the risk of developing systemic-onset juvenile idiopathic arthritis.

4. Ethnicity: Systemic-onset juvenile idiopathic arthritis is more common in people of African, Asian, and Hispanic descent.

5. Infections: Certain infections, such as parvovirus B19, may increase the risk of developing systemic-onset juvenile idiopathic arthritis.

Yes, there are medications and treatments available for Systemic-onset juvenile idiopathic arthritis. Treatment typically includes medications such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying antirheumatic drugs (DMARDs), and biologic agents. Physical therapy, occupational therapy, and other supportive treatments may also be recommended.