Female carriers of Coffin-Lowry syndrome typically experience milder symptoms than males, including mild to moderate intellectual disability, short stature, and skeletal abnormalities. Other common symptoms include facial dysmorphism, cardiac defects, hearing loss, and vision problems.

Common symptoms of Symptomatic form of Coffin-Lowry syndrome in female carriers include:

-Intellectual disability
-Developmental delays
-Growth delays
-Facial features such as a long face, prominent forehead, and a small chin
-Wide-set eyes
-Low-set ears
-Short stature
-Broad hands and feet
-Joint contractures
-Scoliosis
-Heart defects
-Hearing loss
-Seizures
-Behavioral problems
-Speech delays

The cause of Symptomatic form of Coffin-Lowry syndrome in female carriers is a mutation in the RSK2 gene. This gene is responsible for the production of a protein called ribosomal S6 kinase 2, which is involved in the regulation of cell growth and development. Mutations in this gene can lead to a range of physical and mental symptoms, including intellectual disability, skeletal abnormalities, and facial features. Female carriers of the mutation are more likely to experience the more severe form of the syndrome, which is known as the Symptomatic form.

The treatment for Symptomatic form of Coffin-Lowry syndrome in female carriers is focused on managing the symptoms. This may include physical therapy, occupational therapy, speech therapy, and psychological counseling. Medications may also be prescribed to help manage the symptoms, such as antipsychotics, antidepressants, and stimulants. Surgery may be recommended to correct physical deformities or to improve mobility. Genetic counseling is also recommended for female carriers of Coffin-Lowry syndrome.

1. Advanced maternal age
2. Family history of the disorder
3. Maternal exposure to certain medications or environmental toxins
4. Maternal infection during pregnancy
5. Maternal nutritional deficiencies
6. Maternal stress during pregnancy
7. Genetic mutations in the RSK2 gene

At this time, there is no cure for Coffin-Lowry Syndrome. However, there are medications and therapies that can help manage the symptoms. These include medications to help with cognitive and behavioral issues, physical therapy to help with motor skills, and speech therapy to help with communication. Additionally, genetic counseling can help families understand the condition and plan for the future.