About Steroid-responsive encephalopathy associated with autoimmune thyroiditis

What is Steroid-responsive encephalopathy associated with autoimmune thyroiditis?

Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare neurological disorder characterized by inflammation of the brain and spinal cord caused by an autoimmune reaction to the thyroid gland. Symptoms of SREAT include confusion, memory loss, seizures, and difficulty speaking. Treatment typically involves the use of corticosteroids to reduce inflammation and other medications to control symptoms.

What are the symptoms of Steroid-responsive encephalopathy associated with autoimmune thyroiditis?

The most common symptoms of Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) include confusion, memory loss, difficulty concentrating, fatigue, depression, anxiety, irritability, headaches, seizures, and visual disturbances. Other symptoms may include difficulty speaking, difficulty walking, and changes in behavior.

What are the causes of Steroid-responsive encephalopathy associated with autoimmune thyroiditis?

The exact cause of Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is unknown. However, it is believed to be caused by an autoimmune reaction in which the body's immune system mistakenly attacks healthy tissue in the brain. This can lead to inflammation and damage to the brain, resulting in the symptoms of SREAT. Other possible causes include genetic factors, viral infections, and environmental triggers.

What are the treatments for Steroid-responsive encephalopathy associated with autoimmune thyroiditis?

1. Treatment of the underlying autoimmune thyroiditis with thyroid hormone replacement therapy.

2. Corticosteroid therapy to reduce inflammation and suppress the immune system.

3. Immunosuppressive medications such as azathioprine, mycophenolate mofetil, or cyclosporine.

4. Intravenous immunoglobulin (IVIG) therapy.

5. Plasma exchange (plasmapheresis).

6. Anticonvulsant medications to control seizures.

7. Antidepressants to help manage mood symptoms.

8. Physical and occupational therapy to help with motor and cognitive deficits.

What are the risk factors for Steroid-responsive encephalopathy associated with autoimmune thyroiditis?

1. Female gender
2. Autoimmune thyroiditis
3. History of thyroid hormone replacement therapy
4. History of steroid use
5. Genetic predisposition
6. Exposure to environmental toxins
7. Stressful life events
8. Vitamin D deficiency
9. Vitamin B12 deficiency
10. Iron deficiency

Is there a cure/medications for Steroid-responsive encephalopathy associated with autoimmune thyroiditis?

Yes, there are medications and treatments available for Steroid-responsive encephalopathy associated with autoimmune thyroiditis. Treatment typically involves the use of corticosteroids, such as prednisone, to reduce inflammation and suppress the immune system. Other medications, such as anticonvulsants, may be used to control seizures. In some cases, immunosuppressants may be used to reduce the activity of the immune system. Additionally, thyroid hormone replacement therapy may be used to treat any underlying thyroid dysfunction.