Split hand-split foot-deafness syndrome (SHFD) is a rare genetic disorder characterized by the absence of the middle three toes on each foot, split hands, and hearing loss. It is caused by a mutation in the gene that codes for the protein EYA1. Symptoms of SHFD can vary from person to person, but may include webbing of the fingers, syndactyly (fused fingers), and hearing loss. Treatment for SHFD is typically focused on managing the symptoms and may include physical therapy, surgery, and hearing aids.

The symptoms of Split hand-split foot-deafness syndrome (SHFD) vary from person to person, but may include:

-Underdeveloped or missing fingers and/or toes
-Underdeveloped or missing thumbs
-Underdeveloped or missing big toes
-Underdeveloped or missing little toes
-Underdeveloped or missing nails
-Underdeveloped or missing palms
-Underdeveloped or missing soles
-Underdeveloped or missing heel bones
-Underdeveloped or missing ankle bones
-Underdeveloped or missing calf muscles
-Underdeveloped or missing foot arches
-Underdeveloped or missing toes
-Underdeveloped or missing toe joints
-Underdeveloped or missing toe webs
-Underdeveloped or missing toe nails
-Underdeveloped or missing toe pads
-Underdeveloped or missing toe creases
-Underdeveloped or missing toe knuckles

Split hand-split foot-deafness syndrome is caused by a mutation in the SALL1 gene. This gene is responsible for the development of the hands, feet, and ears. The mutation can be inherited from a parent or can occur spontaneously.

Treatment for Split hand-split foot-deafness syndrome is focused on managing the physical and hearing impairments associated with the condition. Treatment may include:

• Physical therapy to improve range of motion and strength in the affected limbs

• Surgery to correct any deformities in the hands or feet

• Hearing aids to improve hearing

• Speech therapy to help with communication

• Occupational therapy to help with daily activities

• Assistive devices such as splints or braces to help with mobility

• Genetic counseling to help families understand the condition and its implications

1. Genetic mutation: Split hand-split foot-deafness syndrome is caused by a mutation in the gene called SALL1.

2. Family history: A family history of the disorder increases the risk of developing the condition.

3. Gender: The disorder is more common in males than females.

4. Ethnicity: Split hand-split foot-deafness syndrome is more common in individuals of Asian descent.

At this time, there is no known cure for Split hand-split foot-deafness syndrome. However, there are medications that can help manage the symptoms associated with the condition. These medications may include anticonvulsants, muscle relaxants, and pain medications. Additionally, physical and occupational therapy can help improve mobility and function.