Split-foot malformation-mesoaxial polydactyly syndrome is a rare genetic disorder characterized by the presence of extra digits on the hands and feet. It is caused by a mutation in the HOXD13 gene, which is responsible for the development of the limbs. People with this condition may have extra toes or fingers, or both, on one or both hands and feet. The extra digits may be fused together or may be separated by a web of skin. In some cases, the extra digits may be malformed or absent.

The most common symptoms of Split-foot malformation-mesoaxial polydactyly syndrome include:

-Extra toes or fingers on the hands and/or feet
-Abnormal fusion of the bones in the hands and/or feet
-Abnormal shape of the hands and/or feet
-Abnormal placement of the toes and/or fingers
-Abnormal webbing between the toes and/or fingers
-Abnormal nails on the hands and/or feet
-Abnormal joint movement in the hands and/or feet
-Pain and discomfort in the hands and/or feet
-Difficulty walking or standing due to the abnormal shape of the feet

Split-foot malformation-mesoaxial polydactyly syndrome is a rare genetic disorder caused by a mutation in the HOXD13 gene. This gene is responsible for the development of the limbs and digits. The mutation in this gene can cause the development of extra digits, as well as the splitting of the foot into two parts. Other causes of this condition include environmental factors, such as exposure to certain chemicals or radiation, as well as certain medications.

The treatment for Split-foot malformation-mesoaxial polydactyly syndrome depends on the severity of the condition and the individual patient. Treatment may include surgical removal of the extra digits, physical therapy to improve mobility, and orthopedic devices such as braces or splints to help support the affected limb. In some cases, reconstructive surgery may be necessary to improve the appearance of the affected limb. In addition, genetic counseling may be recommended to help families understand the condition and its potential implications.

1. Genetic predisposition: Split-foot malformation-mesoaxial polydactyly syndrome is an inherited disorder, meaning it is passed down from parents to their children.

2. Family history: If a family has a history of the disorder, the risk of having a child with the condition is increased.

3. Gender: Split-foot malformation-mesoaxial polydactyly syndrome is more common in males than females.

4. Ethnicity: The disorder is more common in certain ethnic groups, such as African Americans and Native Americans.

Unfortunately, there is no known cure or medications for Split-foot malformation-mesoaxial polydactyly syndrome. Treatment typically involves surgical removal of the extra digits and/or toes. In some cases, reconstructive surgery may be necessary to improve the appearance and function of the affected limb. Physical therapy may also be recommended to help improve range of motion and strength.