SMARCA4-deficient sarcoma of thorax is a rare type of cancer that affects the chest wall and is caused by a mutation in the SMARCA4 gene. This mutation results in the loss of the SMARCA4 protein, which is important for normal cell growth and development. Symptoms of this cancer include chest pain, difficulty breathing, and a lump in the chest. Treatment typically involves surgery, chemotherapy, and radiation therapy.

The symptoms of SMARCA4-deficient sarComa of the thorax can vary depending on the size and location of the tumor. Common symptoms include chest pain, difficulty breathing, coughing, and fatigue. Other symptoms may include a lump or mass in the chest, swelling of the face or neck, and fever.

The exact cause of SMARCA4-deficient sarcoma of the thorax is unknown. However, it is believed to be caused by a mutation in the SMARCA4 gene, which is responsible for the production of a protein that helps regulate cell growth and division. Mutations in this gene can lead to uncontrolled cell growth, which can lead to the development of a tumor.

Treatment for SMARCA4-deficient sarcoma of the thorax typically involves a combination of surgery, chemotherapy, and radiation therapy. Surgery is usually the first line of treatment and may involve removing the tumor and some of the surrounding tissue. Chemotherapy may be used to shrink the tumor before surgery or to reduce the risk of recurrence after surgery. Radiation therapy may be used to reduce the risk of recurrence or to treat any remaining cancer cells. In some cases, targeted therapies such as immunotherapy may be used to help the body's immune system fight the cancer.

1. Genetic mutations in the SMARCA4 gene
2. Exposure to radiation
3. Family history of SMARCA4-deficient sarcoma
4. Exposure to certain chemicals
5. Age (children and young adults are more likely to develop SMARCA4-deficient sarcoma)

At this time, there is no known cure for SMARCA4-deficient sarcoma of the thorax. Treatment typically involves surgery to remove the tumor, followed by chemotherapy and/or radiation therapy. In some cases, targeted therapies such as immunotherapy may be used. Medications such as trastuzumab, cetuximab, and bevacizumab may also be used to help slow the growth of the tumor.