Singleton Merten syndrome is a rare genetic disorder characterized by a combination of physical and developmental abnormalities. It is caused by a mutation in the gene encoding the enzyme lysyl oxidase-like 1 (LOXL1). Symptoms of the disorder include distinctive facial features, skeletal abnormalities, intellectual disability, and hearing loss.

The symptoms of Singleton Merten syndrome vary from person to person, but may include:

-Developmental delay
-Intellectual disability
-Seizures
-Feeding difficulties
-Growth delays
-Hearing loss
-Vision problems
-Heart defects
-Kidney abnormalities
-Abnormalities of the hands and feet
-Cleft lip and/or palate
-Abnormalities of the head and face
-Behavioral problems
-Speech delays

Singleton Merten syndrome is a rare genetic disorder caused by a mutation in the PEX1 gene. This gene is responsible for the production of a protein called peroxisome biogenesis factor 1 (PEX1). This protein is essential for the formation and functioning of peroxisomes, which are small organelles found in cells that are involved in many important metabolic processes. Mutations in the PEX1 gene can lead to a decrease in the amount of PEX1 protein produced, resulting in the development of Singleton Merten syndrome.

The treatments for Singleton Merten syndrome vary depending on the individual and the severity of the condition. Generally, treatment focuses on managing the symptoms and complications associated with the syndrome. This may include physical therapy, occupational therapy, speech therapy, and medications to help with muscle spasms, seizures, and other neurological issues. Surgery may be necessary to correct any physical deformities or to help improve mobility. Additionally, genetic counseling may be recommended to help families understand the condition and its implications.

1. Family history: Singleton Merten syndrome is an inherited disorder, so having a family history of the condition increases the risk of developing it.

2. Age: Singleton Merten syndrome is more common in adults over the age of 40.

3. Gender: Singleton Merten syndrome is more common in males than females.

4. Ethnicity: Singleton Merten syndrome is more common in people of African descent.

At this time, there is no known cure for Singleton Merten Syndrome. However, there are medications that can help manage the symptoms associated with the condition. These medications may include anticonvulsants, muscle relaxants, and medications to help with sleep. Additionally, physical and occupational therapy can help improve motor skills and coordination.