About Schnyder corneal dystrophy

What is Schnyder corneal dystrophy?

Schnyder corneal dystrophy is a rare, inherited eye disorder that affects the cornea, the clear outer layer of the eye. It is characterized by the accumulation of cholesterol and other lipids in the cornea, which can cause vision problems. Symptoms of Schnyder corneal dystrophy include blurred vision, glare, and sensitivity to light. In some cases, the condition can lead to corneal scarring and vision loss. Treatment options include corneal transplantation and laser surgery.

What are the symptoms of Schnyder corneal dystrophy?

The main symptom of Schnyder corneal dystrophy is the presence of yellowish-white deposits in the cornea. These deposits are made up of cholesterol and other lipids and can cause vision problems such as blurred vision, glare, and halos around lights. Other symptoms may include dry eyes, eye irritation, and sensitivity to light.

What are the causes of Schnyder corneal dystrophy?

The exact cause of Schnyder corneal dystrophy is unknown. It is believed to be an inherited disorder caused by a mutation in the UBIAD1 gene. This gene is responsible for producing an enzyme called ubiquinone-binding protein 1, which is involved in cholesterol metabolism.

What are the treatments for Schnyder corneal dystrophy?

1. Corneal transplantation: This is the most effective treatment for Schnyder corneal dystrophy. It involves replacing the affected corneal tissue with healthy donor tissue.

2. Phototherapeutic keratectomy (PTK): This procedure uses a laser to remove the abnormal corneal tissue and replace it with healthy tissue.

3. Corneal collagen cross-linking: This procedure uses ultraviolet light and riboflavin to strengthen the cornea and reduce the risk of further damage.

4. Topical medications: These medications can help reduce inflammation and improve vision.

5. Intracorneal ring segments: These are small plastic rings that are inserted into the cornea to help improve vision.

What are the risk factors for Schnyder corneal dystrophy?

1. Genetic predisposition: Schnyder corneal dystrophy is an autosomal dominant disorder, meaning that it is inherited from one parent.

2. Age: The condition typically begins to manifest in the late teens or early twenties.

3. Gender: Schnyder corneal dystrophy is more common in males than females.

4. Ethnicity: Schnyder corneal dystrophy is more common in individuals of Northern European descent.

Is there a cure/medications for Schnyder corneal dystrophy?

Yes, there are treatments available for Schnyder corneal dystrophy. Treatment options include corneal transplantation, phototherapeutic keratectomy (PTK), and topical medications such as corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs). In some cases, laser surgery may be used to reduce the amount of corneal scarring.