Rotor syndrome is a rare inherited disorder that affects the liver. It is caused by a deficiency of the enzyme uridine diphosphate-glucuronyl transferase (UDPGT), which is responsible for breaking down bilirubin in the liver. Symptoms of Rotor syndrome include jaundice, dark urine, pale stools, and abdominal pain. Treatment typically involves medications to reduce bilirubin levels and dietary changes.

The symptoms of Rotor syndrome vary from person to person, but can include:

-Jaundice (yellowing of the skin and eyes)
-Dark urine
-Pale stools
-Itchy skin
-Abdominal pain
-Nausea and vomiting
-Fatigue
-Weakness
-Weight loss
-Loss of appetite
-Enlarged liver and spleen
-High levels of bilirubin in the blood

Rotor syndrome is a rare inherited disorder caused by a genetic mutation in the gene that codes for the enzyme UDP-glucuronosyltransferase (UGT1A1). This enzyme is responsible for the metabolism of bilirubin, a byproduct of red blood cell breakdown. When the enzyme is not functioning properly, bilirubin builds up in the body, leading to jaundice and other symptoms of Rotor syndrome.

The primary treatment for Rotor syndrome is lifestyle changes, such as reducing salt intake, avoiding alcohol, and exercising regularly. Medications such as diuretics, ACE inhibitors, and angiotensin receptor blockers may also be prescribed to help reduce symptoms. In some cases, surgery may be necessary to remove the gallbladder or to repair any damage to the liver.

1. Family history of Rotor syndrome
2. Being of Mediterranean descent
3. Having a mutation in the ABCB11 gene
4. Having a history of gallstones
5. Being female
6. Being overweight or obese
7. Having a diet high in fat and cholesterol
8. Having a sedentary lifestyle
9. Having a history of alcohol abuse
10. Having a history of smoking

There is no cure for Rotor syndrome, but medications can be used to help manage symptoms. These medications may include diuretics, which help reduce fluid buildup in the body, and medications to reduce cholesterol levels. Other treatments may include lifestyle changes, such as reducing salt intake and increasing physical activity.