Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis (JIA) is a type of juvenile idiopathic arthritis (JIA) that is characterized by inflammation of multiple joints in children and adolescents. It is distinguished from other types of JIA by the absence of rheumatoid factor (RF) in the blood. Symptoms of this condition include joint pain, swelling, and stiffness, as well as fatigue, fever, and weight loss. Treatment typically involves medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic drugs (DMARDs), and biologic agents.

The most common symptoms of Rheumatoid factor-negative polyarticular juvenile idiopathic Arthritis (JIA) include:

• Pain and swelling in multiple joints
• Stiffness in the joints, especially in the morning
• Fatigue
• Low-grade fever
• Weight loss
• Anemia
• Rashes
• Eye inflammation
• Growth problems

The exact cause of rheumatoid factor-negative polyarticular juvenile idiopathic arthritis (JIA) is unknown. However, it is believed to be an autoimmune disorder, meaning that the body’s immune system mistakenly attacks healthy tissue. It is also thought to be triggered by a combination of genetic and environmental factors. Some of the possible environmental factors include infections, such as viruses or bacteria, and exposure to certain toxins.

1. Non-steroidal anti-inflammatory drugs (NSAIDs): These medications reduce inflammation and pain.

2. Disease-modifying antirheumatic drugs (DMARDs): These medications can slow the progression of the disease and reduce joint damage.

3. Corticosteroids: These medications reduce inflammation and can be used to treat severe flares.

4. Biologic agents: These medications target specific parts of the immune system and can be used to treat severe flares.

5. Physical therapy: This can help improve joint range of motion and strength.

6. Occupational therapy: This can help improve daily activities and reduce fatigue.

7. Splints and braces: These can help reduce pain and improve joint function.

8. Surgery: This may be necessary in some cases to repair joint damage.

1. Female gender
2. Age between 6 and 16
3. Family history of autoimmune disease
4. Exposure to environmental toxins
5. Smoking
6. Obesity
7. Vitamin D deficiency
8. Infections
9. Stress

Yes, there are medications and treatments available for rheumatoid factor-negative polyarticular juvenile idiopathic arthritis. Treatment typically includes medications such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying antirheumatic drugs (DMARDs), and biologic agents. Physical therapy and lifestyle modifications such as exercise, stress management, and healthy eating can also help manage symptoms.