RELA fusion-positive ependymoma is a rare type of brain tumor that is characterized by the presence of a specific gene fusion involving the RELA gene. This gene fusion is found in only a small percentage of ependymomas, and it is associated with a more aggressive form of the disease. Treatment for this type of ependymoma typically involves surgery, radiation, and chemotherapy.

The most common symptoms of RELA fusion-positive ependymoma include:

-Headaches
-Nausea and vomiting
-Balance problems
-Weakness or Numbness in the arms or legs
-Seizures
-Personality changes
-Vision changes
-Hearing loss
-Hydrocephalus (buildup of fluid in the brain)
-Difficulty with coordination and movement
-Difficulty with speech or language

The exact cause of RELA fusion-positive ependymoma is unknown. However, it is believed to be related to genetic mutations that occur during embryonic development. These mutations can lead to the fusion of the RELA gene with other genes, resulting in the formation of a tumor. Other potential causes include environmental factors, such as exposure to radiation or certain chemicals, and inherited genetic mutations.

The treatment for RELA fusion-positive ependymoma typically involves a combination of surgery, radiation therapy, and chemotherapy. Surgery is usually the first line of treatment and is used to remove as much of the tumor as possible. Radiation therapy is then used to target any remaining tumor cells. Chemotherapy may also be used to help reduce the size of the tumor and reduce the risk of recurrence.

1. Age: Ependymomas are most commonly diagnosed in children and young adults.

2. Gender: Ependymomas are more common in males than females.

3. Genetics: Certain genetic mutations, such as those involving the RELA gene, have been linked to an increased risk of ependymoma.

4. Exposure to radiation: Exposure to radiation, either through medical treatments or environmental sources, may increase the risk of ependymoma.

5. Family history: Having a family history of ependymoma may increase the risk of developing the disease.

At this time, there is no known cure for RELA fusion-positive ependymoma. However, treatment options may include surgery, radiation therapy, chemotherapy, and targeted therapy. Your doctor will be able to discuss the best treatment plan for you.