Pure mitochondrial myopathy is a rare genetic disorder that affects the mitochondria, the energy-producing structures in cells. It is characterized by muscle weakness and fatigue, as well as other symptoms such as exercise intolerance, muscle cramps, and difficulty breathing. It is caused by mutations in the mitochondrial DNA, which can be inherited from either parent. Treatment typically involves lifestyle modifications, physical therapy, and medications to help manage symptoms.

The symptoms of Pure mitochondrial myopathy can vary depending on the type and severity of the condition, but may include:

- Muscle Weakness and fatigue
- Exercise intolerance
- Muscle cramps
- Muscle pain
- Difficulty walking
- Difficulty swallowing
- Vision problems
- Hearing loss
- Heart problems
- Gastrointestinal problems
- Cognitive and behavioral problems
- Seizures
- Abnormal movements

The most common cause of pure mitochondrial myopathy is a mutation in the mitochondrial DNA. Other causes include mutations in nuclear genes that affect mitochondrial function, inherited metabolic disorders, and exposure to certain toxins.

1. Dietary modifications: Dietary modifications such as a low-fat, low-carbohydrate diet may be recommended to reduce the amount of energy the body needs to produce.

2. Exercise: Exercise can help improve muscle strength and endurance.

3. Medications: Medications such as Coenzyme Q10, Creatine, and L-carnitine may be prescribed to help improve energy production in the mitochondria.

4. Physical therapy: Physical therapy can help improve muscle strength and flexibility.

5. Surgery: Surgery may be recommended in some cases to help improve muscle strength and function.

6. Gene therapy: Gene therapy is a new and experimental treatment that may be used to replace or repair defective mitochondrial genes.

1. Mutations in mitochondrial DNA
2. Inheritance from a parent with a mitochondrial disorder
3. Exposure to certain toxins or medications
4. Advanced age
5. Certain medical conditions, such as diabetes, thyroid disease, or obesity
6. Vitamin deficiencies
7. Certain genetic disorders, such as Friedreich's ataxia or Kearns-Sayre syndrome

There is no cure for pure mitochondrial myopathy, but there are medications that can help manage the symptoms. These medications include coenzyme Q10, riboflavin, and creatine. Other treatments such as physical therapy, occupational therapy, and speech therapy can also help manage the symptoms.