Proton-pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a condition in which the esophagus becomes inflamed due to an increase in the number of eosinophils, a type of white blood cell. This condition is usually caused by acid reflux and is treated with proton-pump inhibitors (PPIs), a type of medication that reduces the amount of acid in the stomach. PPI-REE is a rare condition, but it can cause symptoms such as difficulty swallowing, chest pain, and heartburn.

The most common symptoms of Proton-pump inhibitor-responsive esophageal eosinophilia are:

-Heartburn
-Chest pain
-Difficulty swallowing
-Regurgitation
-Nausea
-Vomiting
-Weight loss
-Anemia
-Abdominal pain
-Asthma-like symptoms
-Hoarseness
-Coughing
-Wheezing

1. Allergic reactions to certain foods, medications, or environmental allergens
2. Gastroesophageal reflux disease (GERD)
3. Eosinophilic esophagitis (EoE)
4. Infections caused by parasites, fungi, or bacteria
5. Use of certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs)
6. Immune system disorders, such as Crohn’s disease or ulcerative colitis
7. Hiatal hernia
8. Radiation therapy to the chest or abdomen

1. Proton-pump inhibitor (PPI) therapy: PPIs are the mainstay of treatment for proton-pump inhibitor-responsive esophageal eosinophilia. PPIs reduce the amount of acid produced in the stomach, which helps to reduce inflammation and improve symptoms.

2. Elimination diet: An elimination diet may be recommended to identify and remove any foods that may be triggering the eosinophilic inflammation.

3. Corticosteroids: Corticosteroids may be prescribed to reduce inflammation and improve symptoms.

4. Antihistamines: Antihistamines may be prescribed to reduce the body’s allergic response to certain foods.

5. Immunomodulators: Immunomodulators, such as cyclosporine, may be prescribed to reduce inflammation and

1. Allergy to certain foods, such as dairy, wheat, and eggs
2. Asthma
3. Gastroesophageal reflux disease (GERD)
4. Use of certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs)
5. Smoking
6. Stress
7. Obesity
8. Eating large meals
9. Eating late at night
10. Eating certain foods, such as spicy foods, citrus fruits, and tomatoes

Yes, there are medications available to treat Proton-pump inhibitor-responsive esophageal eosinophilia. These medications include proton pump inhibitors (PPIs), H2 blockers, and corticosteroids. Additionally, lifestyle modifications such as avoiding certain foods and drinks, eating smaller meals, and avoiding lying down after eating can help reduce symptoms.