Progressive symmetric erythrokeratodermia (PSEK) is a rare genetic skin disorder characterized by symmetrical redness and thickening of the skin on the palms of the hands and soles of the feet. It is caused by a mutation in the GJB3 gene, which is responsible for the production of a protein called connexin 31. Symptoms of PSEK usually begin in childhood and can worsen over time. The condition is not life-threatening, but can cause discomfort and pain. Treatment typically involves topical medications and lifestyle changes.

The symptoms of Progressive symmetric erythrokeratodermia (PSEK) include:

-Red, scaly patches on the skin, usually on the face, neck, chest, and back
-Thickening of the skin
-Itching and Burning sensation
-Thickening of the nails
-Hair loss
-Enlarged sweat glands
-Thickening of the palms and soles of the feet
-Joint Pain and stiffness
-Eye Irritation and dryness

The exact cause of progressive symmetric erythrokeratodermia is unknown. However, it is believed to be an inherited disorder caused by a mutation in the GJB3 gene, which is responsible for the production of a protein called connexin 31. This protein helps to regulate the flow of ions and other molecules between cells. Mutations in this gene can lead to a disruption in the flow of ions and other molecules, resulting in the development of progressive symmetric erythrokeratodermia.

The treatments for Progressive symmetric erythrokeratodermia (PSEK) include topical corticosteroids, topical calcineurin inhibitors, phototherapy, systemic retinoids, and systemic immunosuppressants. In some cases, surgical removal of the affected skin may be necessary.

The exact cause of progressive symmetric erythrokeratodermia is unknown, but it is believed to be an inherited disorder. Risk factors for this condition include:

• Family history of progressive symmetric erythrokeratodermia
• Being of Mediterranean or Middle Eastern descent
• Being male
• Exposure to certain chemicals or drugs, such as phenytoin or carbamazepine

Unfortunately, there is no known cure for progressive symmetric erythrokeratodermia. However, there are medications that can help to manage the symptoms. These include topical corticosteroids, topical calcineurin inhibitors, oral retinoids, and phototherapy. It is important to speak with a doctor to determine the best treatment plan for your individual case.