Progressive Osseous Heteroplasia (POH) is a rare genetic disorder that causes abnormal bone growth in the body. It is caused by a mutation in the GNAS gene, which is responsible for producing the Gsα protein. This protein is involved in the regulation of hormones and other substances in the body. People with POH experience abnormal bone growth in the skin, muscles, and other soft tissues. This can lead to pain, stiffness, and other physical limitations. In some cases, the abnormal bone growth can cause deformities or interfere with normal movement. Treatment for POH is limited and typically focuses on managing symptoms.

The symptoms of Progressive Osseous Heteroplasia (POH) vary from person to person, but generally include the formation of bone-like tissue in the skin, joints, and other soft tissues. Common symptoms include:

-Painful, hard, and immovable lumps in the skin
-Stiffness and limited range of motion in the affected joints
-Painful swelling in the affected joints
-Bone-like tissue formation in the soft tissues of the body
-Bone-like tissue formation in the internal organs
-Bone-like tissue formation in the brain
-Bone-like tissue formation in the eyes
-Bone-like tissue formation in the spinal cord
-Bone-like tissue formation in the heart
-Bone-like tissue formation in the lungs
-Bone-like tissue formation in the kidneys
-Bone

Progressive Osseous Heteroplasia (POH) is a rare genetic disorder caused by mutations in the GNAS gene. The GNAS gene is responsible for producing a protein called Gs alpha, which helps regulate hormones in the body. Mutations in this gene can cause abnormal bone growth, which is the main symptom of POH. Other symptoms may include joint stiffness, muscle weakness, and skin changes. There is currently no cure for POH, but treatments are available to help manage symptoms.

The primary treatment for Progressive Osseous Heteroplasia (POH) is surgical removal of the affected bone. This is usually done to reduce pain and improve mobility. Other treatments may include physical therapy, medications to reduce pain and inflammation, and injections of corticosteroids to reduce swelling. In some cases, radiation therapy may be used to reduce the size of the affected bone. In severe cases, amputation may be necessary.

The exact cause of Progressive Osseous Heteroplasia (POH) is unknown. However, there are some risk factors that may increase the likelihood of developing the condition. These include:

• Family history: POH is an inherited condition, so having a family member with the condition increases the risk of developing it.

• Gender: POH is more common in males than females.

• Age: POH is more likely to occur in children and young adults.

• Ethnicity: POH is more common in people of African descent.

At this time, there is no cure for Progressive Osseous Heteroplasia (POH). However, there are medications that can be used to help manage the symptoms of POH. These medications include non-steroidal anti-inflammatory drugs (NSAIDs), bisphosphonates, and calcitonin. Additionally, physical therapy and occupational therapy can help to improve mobility and reduce pain.