Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome is a rare genetic disorder characterized by a small head size (microcephaly), seizures, cortical blindness, and developmental delay. It is caused by a mutation in the gene that encodes the protein filamin A, which is involved in the formation of the brain's neural networks. Symptoms of the disorder can vary from mild to severe, and may include intellectual disability, motor delays, and vision and hearing problems. Treatment is supportive and may include physical, occupational, and speech therapy, as well as medications to control seizures.

1. Microcephaly (abnormally Small head size)
2. Seizures
3. Cortical Blindness (inability to see)
4. Developmental delay (delayed physical, mental, and/or social development)
5. Poor muscle tone
6. Poor coordination
7. Feeding difficulties
8. Abnormal movements
9. Abnormal reflexes
10. Abnormal breathing patterns
11. Abnormal sleep patterns
12. Abnormal facial features
13. Abnormal growth patterns
14. Intellectual disability

Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome is a rare genetic disorder caused by mutations in the ASPM gene. Mutations in this gene can lead to abnormal brain development, resulting in the symptoms associated with this syndrome. Other causes of this syndrome include chromosomal abnormalities, such as trisomy 13, and certain metabolic disorders.

1. Medication: Anti-seizure medications such as phenobarbital, carbamazepine, and valproic acid may be prescribed to help control seizures.

2. Physical Therapy: Physical therapy can help improve muscle strength and coordination, as well as help with mobility.

3. Occupational Therapy: Occupational therapy can help with activities of daily living, such as dressing, eating, and bathing.

4. Speech Therapy: Speech therapy can help with communication and language development.

5. Vision Therapy: Vision therapy can help with eye-hand coordination and visual perception.

6. Behavioral Therapy: Behavioral therapy can help with social skills and behavior management.

7. Nutritional Therapy: Nutritional therapy can help ensure that the patient is getting the proper nutrition.

8. Assistive Technology:

1. Genetic mutations: Mutations in certain genes, such as ASPM, CDK5RAP2, CENPJ, and WDR62, have been linked to progressive microcephaly-seizures-cortical blindness-developmental delay syndrome.

2. Maternal infections: Maternal infections during pregnancy, such as rubella, cytomegalovirus, and toxoplasmosis, have been linked to progressive microcephaly-seizures-cortical blindness-developmental delay syndrome.

3. Maternal exposure to toxins: Exposure to certain toxins, such as alcohol, drugs, and certain chemicals, during pregnancy has been linked to progressive microcephaly-seizures-cortical blindness-developmental delay syndrome.

4. Maternal malnutrition: Maternal malnutrition

Unfortunately, there is no cure for Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome. However, there are medications that can help manage the symptoms associated with the syndrome. These medications may include anticonvulsants to help control seizures, corticosteroids to reduce inflammation, and medications to help with vision and development. Additionally, physical, occupational, and speech therapy can help with development and functioning.