There is no cure for primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement. Treatment focuses on managing the symptoms and preventing further complications. Medications such as diuretics, calcium-lowering agents, and magnesium supplements may be prescribed to help manage the symptoms. Additionally, lifestyle changes such as increasing fluid intake, reducing dietary calcium, and avoiding certain medications may be recommended.

1. Low dietary intake of magnesium
2. Low levels of parathyroid hormone
3. Renal tubular acidosis
4. Certain medications, such as diuretics, proton pump inhibitors, and antacids
5. Chronic diarrhea or malabsorption
6. Chronic kidney disease
7. Diabetes
8. Hyperthyroidism
9. Hypoparathyroidism
10. Immobility
11. Alcoholism
12. Hypercalciuria
13. Hyperparathyroidism
14. Vitamin D deficiency
15. Genetic mutations

1. Oral magnesium supplementation: This is the mainstay of treatment for primary hypomagnesemia with hypercalciuria and nephrocalcinosis. Oral magnesium supplementation should be given in doses of 1-2 g/day, divided into two or three doses.

2. Dietary modifications: Dietary modifications should be made to reduce the intake of calcium and increase the intake of magnesium. This includes reducing the intake of dairy products, limiting the intake of calcium-rich foods, and increasing the intake of magnesium-rich foods such as nuts, legumes, and green leafy vegetables.

3. Thiazide diuretics: Thiazide diuretics can be used to reduce the absorption of calcium in the gut and increase the excretion of calcium in the urine.

4. Potassium citrate: Potassium citrate can

Primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement can be caused by a variety of genetic and environmental factors. Genetic causes include mutations in the TRPM6 gene, which is responsible for magnesium transport in the body, and mutations in the SLC34A3 gene, which is responsible for phosphate transport. Environmental causes include a diet low in magnesium, excessive intake of calcium, and excessive intake of vitamin D. Other causes include certain medications, such as diuretics, and certain medical conditions, such as chronic kidney disease and diabetes.

The symptoms of Primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement include:

-Fatigue
-Muscle weakness
-Tremors
-Nausea
-Vomiting
-Loss of appetite
-Abdominal pain
-Constipation
-Dehydration
-Confusion
-Seizures
-Cardiac arrhythmias
-High blood pressure
-Ocular symptoms such as blurred vision, double vision, and photophobia

Primary hypomagnesemia with hypercalciuria and nephrocalcinosis with severe ocular involvement is a rare inherited disorder caused by a mutation in the TRPM6 gene. It is characterized by low levels of magnesium in the blood, high levels of calcium in the urine, and the formation of calcium deposits in the kidneys. It can also cause severe eye problems, including vision loss, cataracts, and glaucoma. Treatment typically involves taking magnesium supplements and avoiding foods high in calcium.