At this time, there is no cure for primary hyperoxaluria type 3. However, medications may be used to help manage the symptoms and slow the progression of the disease. These medications include allopurinol, which helps reduce the amount of oxalate in the body, and vitamin B6, which helps reduce the amount of oxalate produced by the liver. Additionally, dietary changes may be recommended to reduce the amount of oxalate in the diet.

The risk factors for Primary hyperoxaluria type 3 include:

1. Genetic predisposition: Primary hyperoxaluria type 3 is caused by a mutation in the GRHPR gene, which is inherited in an autosomal recessive pattern.

2. Age: Primary hyperoxaluria type 3 is more common in children and young adults.

3. Gender: Primary hyperoxaluria type 3 is more common in males than females.

4. Ethnicity: Primary hyperoxaluria type 3 is more common in people of European descent.

The primary treatment for Primary Hyperoxaluria Type 3 is a low-oxalate diet. This diet should include foods that are low in oxalate, such as fruits, vegetables, and grains. Additionally, it is important to limit the intake of foods that are high in oxalate, such as nuts, chocolate, and spinach.

In addition to dietary changes, medications may be prescribed to help reduce the amount of oxalate in the body. These medications include pyridoxine (vitamin B6), ascorbic acid (vitamin C), and calcium citrate.

In some cases, a liver transplant may be recommended to help reduce the amount of oxalate in the body. This procedure is usually reserved for those with severe cases of Primary Hyperoxaluria Type 3.

Primary hyperoxaluria type 3 is caused by mutations in the GRHPR gene. This gene provides instructions for making an enzyme called glyoxylate reductase/hydroxypyruvate reductase (GRHPR). This enzyme helps break down certain molecules in the body, including oxalate. Mutations in the GRHPR gene reduce or eliminate the activity of the GRHPR enzyme, leading to an accumulation of oxalate in the body and the development of primary hyperoxaluria type 3.

The symptoms of Primary hyperoxaluria type 3 vary from person to person, but may include:

-Pain in the lower back, abdomen, or sides
-Frequent urination
-Cloudy or bloody urine
-Painful urination
-Fever
-Nausea and vomiting
-Fatigue
-Loss of appetite
-Weight loss
-Joint pain
-Itching
-Skin rash
-Kidney stones
-Kidney failure

Primary hyperoxaluria type 3 (PH3) is a rare inherited disorder caused by a deficiency of the enzyme alanine-glyoxylate aminotransferase (AGT). This enzyme is involved in the metabolism of the amino acid alanine and the breakdown of oxalate, a byproduct of metabolism. People with PH3 have an accumulation of oxalate in their bodies, which can lead to kidney stones, kidney failure, and other health problems.