At this time, there is no cure for prenatal-onset spinal muscular atrophy with congenital bone fractures. Treatment focuses on managing symptoms and preventing complications. Medications such as baclofen, diazepam, and dantrolene may be used to reduce muscle spasms and improve mobility. Physical and occupational therapy can help improve strength, coordination, and range of motion. Surgery may be necessary to correct any bone deformities.

1. Family history of spinal muscular atrophy (SMA)
2. Maternal age over 35
3. Maternal smoking during pregnancy
4. Maternal alcohol consumption during pregnancy
5. Maternal use of certain medications during pregnancy
6. Maternal exposure to certain environmental toxins during pregnancy
7. Maternal nutritional deficiencies during pregnancy
8. Maternal infection during pregnancy
9. Maternal diabetes during pregnancy
10. Maternal obesity during pregnancy

1. Physical therapy: Physical therapy can help to improve strength, flexibility, and range of motion in affected muscles.

2. Occupational therapy: Occupational therapy can help to improve fine motor skills, such as writing and using utensils, as well as activities of daily living.

3. Bracing: Bracing can help to support weakened muscles and joints, and can help to prevent further fractures.

4. Surgery: Surgery may be necessary to repair fractures or to correct any deformities caused by the condition.

5. Medications: Medications such as muscle relaxants and pain relievers may be prescribed to help manage symptoms.

6. Nutritional support: A balanced diet and nutritional supplements may be recommended to help maintain muscle strength and health.

Prenatal-onset spinal muscular atrophy with congenital bone fractures is caused by mutations in the SMN1 gene. This gene is responsible for producing the survival motor neuron protein, which is essential for the development and maintenance of motor neurons. Mutations in this gene can lead to a decrease in the amount of this protein, resulting in the development of spinal muscular atrophy and congenital bone fractures.

Symptoms of Prenatal-onset spinal muscular Atrophy with congenital bone fractures include:

-Weakness and Decreased muscle tone in the arms and legs
-Loss of reflexes
-Difficulty breathing
-Difficulty swallowing
-Scoliosis
-Contractures of the joints
-Congenital bone fractures
-Delayed motor milestones
-Delayed speech and language development
-Difficulty with fine motor skills
-Difficulty with gross motor skills
-Difficulty with balance and coordination
-Seizures
-Intellectual disability

Prenatal-onset spinal muscular atrophy with congenital bone fractures is a rare genetic disorder that affects the development of the spinal cord and muscles. It is characterized by the onset of muscle weakness and wasting before birth, as well as congenital bone fractures. This disorder is caused by a mutation in the SMN1 gene, which is responsible for producing the survival motor neuron protein. This protein is essential for the development and maintenance of motor neurons, which are responsible for controlling muscle movement. Without this protein, the motor neurons are unable to function properly, leading to muscle weakness and wasting.