At this time, there is no cure for PGM3-CDG. However, there are medications that can help manage the symptoms of the disorder. These include medications to help with seizures, muscle spasms, and other neurological symptoms. Additionally, physical and occupational therapy can help improve mobility and coordination.

The risk factors for PGM3-CDG include:

1. Family history of the disorder
2. Mutation in the PGM3 gene
3. Consanguinity (marriage between close relatives)
4. Advanced maternal age
5. Exposure to certain environmental toxins or medications during pregnancy.

Currently, there is no cure for PGM3-CDG. Treatment focuses on managing the symptoms and complications of the condition. This may include physical therapy, occupational therapy, speech therapy, dietary modifications, and medications to manage seizures, pain, and other symptoms. In some cases, surgery may be recommended to correct physical abnormalities.

PGM3-CDG is caused by mutations in the PGM3 gene. This gene provides instructions for making an enzyme called phosphoglucomutase-3 (PGM3). This enzyme is involved in the metabolism of carbohydrates, which are molecules that provide energy to the body. Mutations in the PGM3 gene reduce or eliminate the activity of the PGM3 enzyme, leading to a buildup of certain carbohydrates in the body and the signs and symptoms of PGM3-CDG.

The symptoms of PGM3-CDG vary from person to person, but may include:

-Developmental delays
-Intellectual disability
-Seizures
-Feeding difficulties
-Growth delays
-Hearing loss
-Vision problems
-Muscle weakness
-Coordination problems
-Heart defects
-Kidney problems
-Gastrointestinal issues
-Skin rashes
-Skeletal abnormalities

PGM3-CDG is a rare genetic disorder caused by a mutation in the PGM3 gene. It is characterized by a wide range of physical and neurological symptoms, including intellectual disability, seizures, movement disorders, and facial dysmorphism.