At this time, there is no known cure or medication for persistent left superior vena cava connecting to the roof of left-sided atrium. Treatment typically involves surgical repair of the defect. The goal of the surgery is to restore normal blood flow and prevent any further complications.

1. Congenital heart defects
2. Abnormalities in the development of the heart
3. Premature birth
4. Genetic predisposition
5. Exposure to certain medications or toxins
6. Exposure to radiation
7. Infections during pregnancy
8. Maternal diabetes or high blood pressure during pregnancy

1. Transcatheter closure: This is a minimally invasive procedure that involves the insertion of a device into the left superior vena cava to close off the connection.

2. Surgical repair: This involves surgically opening the chest and repairing the connection between the left superior vena cava and the roof of the left-sided atrium.

3. Medical management: This involves the use of medications to reduce the symptoms associated with the condition. These medications may include diuretics, beta-blockers, and ACE inhibitors.

Persistent left superior vena cava connecting to the roof of left-sided atrium is a congenital heart defect that is caused by abnormal development of the fetal heart during the early stages of pregnancy. It is believed to be caused by a combination of genetic and environmental factors, such as maternal smoking, alcohol consumption, and certain medications.

The symptoms of Persistent left superior vena cava connecting to the roof of left-sided atrium may include:

-Shortness of breath
-Fatigue
-Palpitations
-Chest pain
-Lightheadedness
-Swelling of the face, neck, and arms
-Cyanosis (bluish discoloration of the skin)
-Low blood pressure
-Abnormal heart rhythms (arrhythmias)
-Heart murmur
-Enlarged heart (cardiomegaly)

Persistent left superior vena cava (PLSVC) is a rare congenital heart defect in which the left superior vena cava (the vein that carries deoxygenated blood from the upper body to the heart) connects to the roof of the left-sided atrium instead of the right-sided atrium. This can cause a variety of symptoms, including shortness of breath, fatigue, and chest pain. Treatment typically involves corrective surgery to reroute the vein to the right-sided atrium.