Non-syndromic unifrontosphenoidal craniosynostosis is a type of craniosynostosis, which is a condition in which the bones of the skull fuse together too early. In this particular type, the fusion occurs between the frontal and sphenoid bones of the skull. This can cause the skull to become misshapen and can lead to a range of complications, including vision and hearing problems, developmental delays, and increased pressure on the brain. Treatment typically involves surgery to reshape the skull and release the pressure on the brain.

The most common symptoms of non-syndromic unifrontosphenoidal craniosynostosis include:

-A head shape that is abnormally long and narrow
-A prominent forehead
-A flat back of the head
-A wide space between the eyes
-A flattened bridge of the nose
-A wide space between the upper lip and nose
-A wide space between the lower lip and chin
-A wide space between the ears
-A wide space between the eyes and ears
-A wide space between the eyes and eyebrows
-A wide space between the eyebrows and hairline
-A wide space between the eyes and hairline
-A wide space between the ears and hairline
-A wide space between the eyes and temples
-A wide space between the ears and temples
-A wide

Non-syndromic unifrontosphenoidal craniosynostosis is a rare condition that is caused by a combination of genetic and environmental factors. Genetic factors include mutations in certain genes that are involved in the development of the skull, such as FGFR2, TWIST1, and MSX2. Environmental factors may include maternal smoking, alcohol consumption, and exposure to certain medications during pregnancy.

1. Endoscopic strip craniectomy: This procedure involves removing the fused sutures and reshaping the skull.

2. Cranial vault remodeling: This procedure involves reshaping the skull to create a more symmetrical appearance.

3. Cranial osteotomy: This procedure involves cutting and reshaping the bones of the skull to create a more symmetrical appearance.

4. Cranioplasty: This procedure involves using a synthetic material to fill in any gaps or depressions in the skull.

5. Cranial distraction: This procedure involves using a device to slowly separate the fused sutures and reshape the skull.

6. Surgery to correct any associated problems: This may include correcting any vision or hearing problems, or any other associated problems.

1. Family history of craniosynostosis
2. Premature birth
3. Low birth weight
4. Exposure to certain medications or drugs during pregnancy
5. Exposure to radiation during pregnancy
6. Maternal diabetes
7. Maternal smoking during pregnancy
8. Maternal alcohol consumption during pregnancy

At this time, there is no cure for non-syndromic unifrontosphenoidal craniosynostosis. Treatment typically involves surgery to correct the skull deformity and to allow for normal brain growth. Medications may be prescribed to help manage pain and discomfort associated with the condition.