Non-syndromic unicoronal and sagittal craniosynostosis is a type of craniosynostosis, which is a condition in which the bones of the skull fuse together too early. In this type of craniosynostosis, only one of the coronal sutures (the sutures that run from ear to ear) and the sagittal suture (the suture that runs from front to back) are affected. This can cause the head to become misshapen and can lead to developmental delays and other health problems. Treatment typically involves surgery to separate the fused sutures and reshape the skull.

Symptoms of non-syndromic unicoronal and sagittal craniosynostosis can include:

-Head shape that is long and narrow
-High forehead
-Widely spaced eyes
-Flattened back of the head
-Bulging fontanelle (soft spot)
-Delayed motor development
-Delayed speech development
-Delayed cognitive development
-Sleep apnea
-Vision problems
-Hearing problems
-Seizures
-Hydrocephalus (buildup of fluid in the brain)

Non-syndromic unicoronal and sagittal craniosynostosis are caused by a combination of genetic and environmental factors. Genetic factors include mutations in certain genes, such as FGFR2, TWIST1, and MSX2. Environmental factors include maternal smoking, alcohol consumption, and certain medications taken during pregnancy.

Non-syndromic unicoronal and sagittal craniosynostosis are typically treated with surgery. The goal of the surgery is to reshape the skull and allow for normal brain growth. The surgery is usually done when the child is between 3 and 12 months old. After the surgery, the child may need to wear a helmet to help reshape the skull and protect it from further damage. Other treatments may include physical therapy, occupational therapy, and speech therapy to help the child reach their developmental milestones.

1. Family history of craniosynostosis
2. Premature birth
3. Low birth weight
4. Exposure to certain medications or drugs during pregnancy
5. Exposure to radiation during pregnancy
6. Maternal diabetes
7. Maternal smoking during pregnancy
8. Maternal alcohol consumption during pregnancy
9. Maternal obesity

Non-syndromic unicoronal and sagittal craniosynostosis are treated with surgery. The goal of the surgery is to reshape the skull and allow for normal brain growth. Medications are not typically used to treat this condition.