Non-syndromic non-specific multisutural craniosynostosis is a type of craniosynostosis, which is a condition in which the sutures (the joints between the bones of the skull) close too early. In non-syndromic non-specific multisutural craniosynostosis, multiple sutures close prematurely, but the cause is unknown and the condition is not associated with any other medical conditions. This type of craniosynostosis can cause the skull to become misshapen and can lead to developmental delays and other medical problems. Treatment typically involves surgery to open the sutures and reshape the skull.

The most common symptoms of non-syndromic non-specific multisutural craniosynostosis include:

-Abnormal head shape
-Bulging of the forehead
-Flattening of the back of the head
-Widely spaced eyes
-Highly arched eyebrows
-Widely spaced ears
-Crowding of the teeth
-Delayed development of motor skills
-Delayed development of language skills
-Delayed development of social skills
-Impaired vision
-Impaired hearing
-Seizures
-Hydrocephalus (buildup of fluid in the brain)

Non-syndromic non-specific multisutural craniosynostosis is a rare condition that is caused by a combination of genetic and environmental factors. Genetic factors include mutations in certain genes that are involved in the development of the skull, such as FGFR2, TWIST1, and MSX2. Environmental factors include maternal smoking, alcohol consumption, and exposure to certain medications during pregnancy.

1. Endoscopic strip craniectomy: This procedure involves removing strips of bone from the sutures to allow for more space in the skull.

2. Cranial vault remodeling: This procedure involves reshaping the skull to create more space and reduce pressure on the brain.

3. Cranial vault expansion: This procedure involves surgically inserting a device into the skull to expand the skull and create more space.

4. Shunt placement: This procedure involves placing a shunt in the brain to reduce pressure and allow for more space in the skull.

5. Cranial osteotomy: This procedure involves surgically cutting and reshaping the skull to create more space.

6. Cranioplasty: This procedure involves surgically replacing the skull with a synthetic material to create more space.

1. Family history of craniosynostosis
2. Premature birth
3. Low birth weight
4. Exposure to certain medications or drugs during pregnancy
5. Exposure to radiation during pregnancy
6. Maternal diabetes
7. Maternal smoking during pregnancy
8. Maternal alcohol consumption during pregnancy
9. Maternal obesity

At this time, there is no cure for non-syndromic non-specific multisutural craniosynostosis. Treatment typically involves surgery to correct the shape of the skull and to allow for normal brain growth. Medications may be prescribed to help manage pain and discomfort associated with the condition.