Non-syndromic anorectal malformation without fistula is a type of birth defect in which the rectum and anus do not form properly. This type of malformation does not involve any other organs or body systems, and there is no connection between the rectum and the outside of the body. Symptoms may include constipation, difficulty passing stool, and soiling. Treatment typically involves surgery to correct the malformation and create a normal connection between the rectum and anus.

The symptoms of Non-syndromic anorectal malformation without fistula include:

-Difficulty passing stool
-Painful bowel movements
-Constipation
-Fecal incontinence
-Abdominal distention
-Abdominal pain
-Rectal bleeding
-Foul-smelling discharge from the rectum
-Abnormal positioning of the anus

1. Genetic factors: Mutations in certain genes, such as the HOXA gene, have been linked to anorectal malformations without fistula.

2. Environmental factors: Exposure to certain environmental toxins, such as certain pesticides, may increase the risk of anorectal malformations without fistula.

3. Maternal factors: Maternal diabetes, obesity, and smoking during pregnancy have been linked to an increased risk of anorectal malformations without fistula.

4. Congenital anomalies: Certain congenital anomalies, such as imperforate anus, may lead to anorectal malformations without fistula.

1. Surgery: Surgery is the most common treatment for non-syndromic anorectal malformation without fistula. The goal of the surgery is to create a normal anal opening and to restore normal anatomy.

2. Bowel Management: Bowel management is a treatment option for non-syndromic anorectal malformation without fistula. This involves a combination of diet, lifestyle changes, and medications to help manage the symptoms of the condition.

3. Stool Softeners: Stool softeners are medications that help to soften the stool and make it easier to pass. This can help to reduce the risk of constipation and other complications associated with non-syndromic anorectal malformation without fistula.

4. Biofeedback: Biofeedback is a type of therapy that

1. Family history of anorectal malformation
2. Maternal diabetes
3. Maternal smoking
4. Maternal obesity
5. Maternal use of certain medications
6. Maternal exposure to certain environmental toxins
7. Maternal age over 35
8. Low birth weight
9. Premature birth
10. Male gender

Yes, there are treatments available for non-syndromic anorectal malformation without fistula. Treatment options include surgical repair, which can be done in a single stage or multiple stages, depending on the severity of the malformation. Other treatments include medications to reduce inflammation and pain, as well as physical therapy to help improve muscle strength and function.