Non-amyloid fibrillary glomerulopathy (NAFG) is a rare kidney disorder characterized by the accumulation of abnormal proteins in the glomeruli, the tiny filters in the kidneys that help to remove waste from the blood. Symptoms of NAFG include proteinuria (excess protein in the urine), hematuria (blood in the urine), and edema (swelling). Treatment typically involves medications to reduce proteinuria and control blood pressure.

The symptoms of Non-amyloid fibrillary glomerulopathy can vary depending on the severity of the condition. Common symptoms include:

- Proteinuria (excess protein in the urine)
- Hematuria (blood in the urine)
- Edema (swelling)
- Hypertension (high blood pressure)
- Renal insufficiency (decreased kidney function)
- Renal failure
- Fatigue
- Loss of appetite
- Weight loss
- Nausea
- Vomiting
- Abdominal pain
- Itching

The exact cause of non-amyloid fibrillary glomerulopathy is unknown. However, it is believed to be related to an abnormal accumulation of proteins in the glomeruli, which are the tiny filters in the kidneys that remove waste from the blood. Possible causes of this accumulation include genetic mutations, autoimmune diseases, and certain medications.

1. ACE inhibitors and angiotensin receptor blockers (ARBs): These medications help reduce proteinuria and slow the progression of kidney disease.

2. Diuretics: These medications help reduce fluid retention and swelling.

3. Immunosuppressants: These medications help reduce inflammation and slow the progression of kidney disease.

4. Corticosteroids: These medications help reduce inflammation and slow the progression of kidney disease.

5. Plasma exchange: This procedure helps remove abnormal proteins from the blood.

6. Kidney transplant: This procedure replaces the damaged kidney with a healthy one.

1. Advanced age
2. Diabetes
3. Hypertension
4. Chronic kidney disease
5. Systemic lupus erythematosus
6. Autoimmune diseases
7. Exposure to certain drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs)
8. Exposure to certain toxins, such as lead or mercury
9. Genetic predisposition

There is no known cure for non-amyloid fibrillary glomerulopathy. Treatment is focused on managing the symptoms and complications of the condition. Medications such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and diuretics may be prescribed to help reduce proteinuria and slow the progression of the disease. Corticosteroids and immunosuppressants may also be used to reduce inflammation and slow the progression of the disease.