About Neonatal Cholestasis

What is Neonatal Cholestasis?

Neonatal cholestasis is a condition in which bile flow from the liver is blocked or reduced in newborn babies. It can cause jaundice, itching, and poor growth. It is usually caused by a genetic disorder, but can also be caused by certain infections or medications. Treatment typically involves medications to reduce the symptoms and improve bile flow.

What are the symptoms of Neonatal Cholestasis?

The symptoms of Neonatal Cholestasis include:

-Jaundice (yellowing of the skin and eyes)
-Dark urine
-Light-colored stools
-Itching
-Poor weight gain
-Lethargy
-Vomiting
-Diarrhea
-Fever
-Abdominal pain
-Failure to thrive

What are the causes of Neonatal Cholestasis?

Neonatal cholestasis is a condition in which bile flow from the liver is blocked or reduced. It can be caused by a variety of factors, including genetic disorders, infections, metabolic disorders, and medications. In some cases, the cause is unknown.

What are the treatments for Neonatal Cholestasis?

The treatment for Neonatal Cholestasis depends on the underlying cause. Treatment options may include:

1. Medications: Medications such as Ursodeoxycholic acid (UDCA) and S-adenosylmethionine (SAMe) may be prescribed to reduce the amount of bile acids in the blood and improve liver function.

2. Dietary changes: A low-fat diet may be recommended to reduce the amount of bile acids in the blood.

3. Surgery: In some cases, surgery may be necessary to remove a blockage or repair a damaged bile duct.

4. Liver transplant: In severe cases, a liver transplant may be necessary.

What are the risk factors for Neonatal Cholestasis?

1. Prematurity
2. Low birth weight
3. Maternal diabetes
4. Maternal drug use
5. Maternal infections
6. Genetic disorders
7. Congenital anomalies
8. Exposure to toxins
9. Exposure to certain medications
10. Metabolic disorders

Is there a cure/medications for Neonatal Cholestasis?

Yes, there are treatments available for Neonatal Cholestasis. Treatment typically involves medications to reduce the amount of bile acids in the blood, such as Ursodeoxycholic acid (UDCA). Other medications, such as rifampin, may also be used to reduce the amount of bile acids in the blood. In some cases, a liver transplant may be necessary.