Multiple epiphyseal dysplasia, Al-Gazali type (MED-AG) is a rare genetic disorder that affects the growth of bones in the body. It is characterized by short stature, joint pain, and skeletal abnormalities. People with MED-AG may have a short stature, short limbs, and a short neck. They may also have joint pain, stiffness, and limited range of motion. Other features may include a curved spine, bowed legs, and a waddling gait.

The symptoms of Multiple epiphyseal dysplasia, Al-Gazali type include:

-Short stature
-Joint pain
-Delayed closure of the growth plates in the long bones
-Hip and knee pain
-Flat feet
-Limited range of motion in the hips, knees, and ankles
-Bowed legs
-Waddling gait
-Frequent dislocations of the shoulder and elbow
-Scoliosis
-Kyphosis
-Frequent fractures
-Abnormal curvature of the spine
-Abnormal curvature of the ribs
-Enlarged wrists and ankles
-Enlarged epiphyses (the ends of the long bones)
-Enlarged joints
-Enlarged head
-Enlarged forehead
-Widely

Multiple epiphyseal dysplasia, Al-Gazali type is caused by a mutation in the COMP gene. This gene provides instructions for making a protein called cartilage oligomeric matrix protein (COMP). This protein is important for the formation and maintenance of cartilage, which is a type of connective tissue that makes up much of the skeleton during early development. Mutations in the COMP gene lead to the production of an abnormal COMP protein, which disrupts the development of cartilage and other tissues.

The treatments for Multiple epiphyseal dysplasia, Al-Gazali type, vary depending on the severity of the condition and the individual's symptoms. Treatment may include physical therapy, occupational therapy, and orthopedic surgery to correct joint deformities. Pain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), may be prescribed to reduce pain and inflammation. In some cases, braces or splints may be used to support weakened joints. Surgery may be necessary to correct joint deformities or to replace damaged joints. In severe cases, joint replacement surgery may be necessary.

1. Genetic mutation: Multiple epiphyseal dysplasia, Al-Gazali type is caused by a mutation in the COMP gene.

2. Family history: Multiple epiphyseal dysplasia, Al-Gazali type is inherited in an autosomal recessive pattern, which means both parents must carry the mutated gene for a child to be affected.

3. Age: Multiple epiphyseal dysplasia, Al-Gazali type is usually diagnosed in childhood.

At this time, there is no cure for Multiple epiphyseal dysplasia, Al-Gazali type. Treatment focuses on managing the symptoms and complications associated with the condition. This may include physical therapy, occupational therapy, and medications to help manage pain and inflammation. Surgery may be recommended to correct joint deformities or to stabilize joints.