About Microvillus Inclusion Disease

What is Microvillus Inclusion Disease?

Microvillus Inclusion Disease (MVID) is a rare genetic disorder that affects the small intestine. It is caused by a mutation in the MYO5B gene, which is responsible for the production of a protein that helps to form the microvilli in the small intestine. People with MVID have an abnormally low number of microvilli, which affects their ability to absorb nutrients from food. Symptoms of MVID include chronic diarrhea, failure to thrive, and electrolyte imbalances. Treatment typically involves a combination of dietary changes, medications, and supplements.

What are the symptoms of Microvillus Inclusion Disease?

The symptoms of Microvillus Inclusion Disease (MVID) vary from person to person, but the most common symptoms include:

-Chronic diarrhea
-Malnutrition
-Failure to thrive
-Abdominal pain
-Dehydration
-Weight loss
-Electrolyte imbalances
-Vomiting
-Liver dysfunction
-Growth retardation
-Hypoglycemia
-Low blood calcium levels
-Low blood magnesium levels
-Low blood potassium levels
-Low blood sodium levels
-Low blood chloride levels
-Low blood bicarbonate levels
-Low blood phosphate levels
-Low blood albumin levels
-Low blood urea nitrogen levels
-Low blood creatinine levels
-Low blood uric acid levels
-Low blood amylase levels
-Low

What are the causes of Microvillus Inclusion Disease?

Microvillus Inclusion Disease (MVID) is a rare genetic disorder caused by mutations in the MYO5B gene. This gene is responsible for the production of a protein called myosin Vb, which is essential for the normal functioning of the small intestine. Mutations in this gene lead to the formation of abnormal microvilli, which are small projections on the surface of the cells that line the small intestine. These abnormal microvilli are unable to absorb nutrients, leading to malabsorption and malnutrition.

What are the treatments for Microvillus Inclusion Disease?

The primary treatment for Microvillus Inclusion Disease (MVID) is supportive care. This includes providing adequate nutrition and hydration, as well as managing any associated symptoms. Medications may be used to reduce inflammation in the intestines, reduce diarrhea, and improve absorption of nutrients. Surgery may be necessary to remove parts of the intestine that are severely damaged. In some cases, a transplant of the small intestine may be necessary.

What are the risk factors for Microvillus Inclusion Disease?

1. Genetic mutations in the MYO5B gene
2. Autosomal recessive inheritance
3. Maternal consanguinity
4. Premature birth
5. Low birth weight
6. Intestinal obstruction
7. Intestinal perforation
8. Abdominal distention
9. Poor feeding
10. Vomiting
11. Diarrhea
12. Malabsorption
13. Protein-losing enteropathy
14. Hypoalbuminemia
15. Hypocalcemia
16. Hypomagnesemia
17. Hypokalemia
18. Metabolic acidosis
19. Hypotonia
20. Failure to thrive

Is there a cure/medications for Microvillus Inclusion Disease?

At this time, there is no cure for Microvillus Inclusion Disease (MID). However, there are medications that can help manage the symptoms of MID. These medications include antidiarrheal agents, antibiotics, and anti-inflammatory medications. Additionally, nutritional support and dietary modifications may be recommended to help manage the symptoms of MID.