Mesomelia-synostoses syndrome is a rare genetic disorder characterized by shortening of the limbs, particularly the arms and legs. It is caused by the premature fusion of certain bones in the arms and legs, resulting in a shortened limb length. Other features of the disorder may include joint contractures, scoliosis, and facial abnormalities.

The symptoms of Mesomelia-synostoses syndrome include:

-Short stature
-Abnormal bone growth
-Underdeveloped or absent ribs
-Abnormal curvature of the spine
-Abnormal joint development
-Abnormal facial features
-Hearing loss
-Cleft palate
-Heart defects
-Kidney abnormalities
-Intellectual disability
-Seizures
-Delayed development

Mesomelia-synostoses syndrome is a rare genetic disorder caused by mutations in the FGFR3 gene. This gene is responsible for the production of a protein that helps regulate the growth of bones. Mutations in this gene can lead to abnormal bone growth, resulting in mesomelia (short limbs) and synostoses (abnormal fusion of bones).

The primary treatment for Mesomelia-synostoses syndrome is surgery to correct the skeletal deformities. This may include lengthening of the affected limb, osteotomies to correct the deformities, and joint fusions to stabilize the joints. Physical therapy and occupational therapy may also be recommended to help improve range of motion and strength. In some cases, orthopedic braces may be used to help support the affected limb.

1. Genetic mutation: Mesomelia-synostoses syndrome is caused by a mutation in the gene called GDF5.

2. Family history: Individuals with a family history of Mesomelia-synostoses syndrome are at an increased risk of developing the condition.

3. Gender: Mesomelia-synostoses syndrome is more common in males than females.

4. Age: The condition is more likely to occur in infants and young children.

At this time, there is no cure for Mesomelia-synostoses syndrome. Treatment focuses on managing the symptoms and complications associated with the condition. This may include physical therapy, occupational therapy, orthopedic surgery, and medications to help manage pain.