Lethal intrauterine growth restriction-cortical malformation-congenital contractures syndrome (LIGRCMC) is a rare genetic disorder characterized by severe intrauterine growth restriction, cortical malformations, and congenital contractures. It is caused by a mutation in the gene encoding the transcription factor FOXP2. Affected individuals typically have severe growth restriction, microcephaly, and multiple congenital contractures. Other features may include facial dysmorphism, intellectual disability, and seizures. The prognosis for individuals with this disorder is poor, with most affected individuals not surviving beyond infancy.

The symptoms of Lethal intrauterine growth restriction-cortical malformation-congenital contractures syndrome include:

-Severe intrauterine growth restriction
-Cortical malformation
-Microcephaly
-Severe hypotonia
-Seizures
-Developmental delay
-Feeding difficulties
-Respiratory distress
-Congenital contractures
-Abnormal facial features
-Cardiac defects
-Renal anomalies
-Gastrointestinal anomalies
-Hearing loss
-Vision impairment
-Hypoglycemia

1. Genetic mutations or chromosomal abnormalities
2. Maternal infections, such as rubella, cytomegalovirus, or toxoplasmosis
3. Maternal health conditions, such as diabetes, hypertension, or lupus
4. Maternal drug or alcohol use
5. Poor nutrition
6. Placental abnormalities
7. Uterine abnormalities
8. Exposure to environmental toxins
9. Poor maternal health care

Unfortunately, there is no known cure for Lethal intrauterine growth restriction-cortical malformation-congenital contractures syndrome. Treatment is focused on managing the symptoms and providing supportive care. This may include physical therapy to help improve mobility, occupational therapy to help with daily activities, and speech therapy to help with communication. Medications may also be prescribed to help manage pain and other symptoms. In some cases, surgery may be recommended to help improve mobility and function.

1. Advanced maternal age
2. Maternal smoking
3. Maternal alcohol consumption
4. Maternal diabetes
5. Maternal obesity
6. Maternal hypertension
7. Maternal infection
8. Maternal exposure to certain medications
9. Maternal exposure to environmental toxins
10. Maternal nutritional deficiencies
11. Multiple pregnancies
12. Placental abnormalities
13. Genetic factors

Unfortunately, there is no known cure or medications for Lethal intrauterine growth restriction-cortical malformation-congenital contractures syndrome. Treatment is focused on managing the symptoms and providing supportive care. This may include physical therapy, occupational therapy, and speech therapy to help with motor and communication skills. Medications may be prescribed to help with pain, seizures, and other symptoms.