Juvenile CACH Syndrome (also known as JCAH or Juvenile Chronic Arthritis with Hypereosinophilia) is a rare, inherited disorder characterized by chronic arthritis, hypereosinophilia (an abnormally high number of eosinophils, a type of white blood cell), and other symptoms. It is caused by a mutation in the gene encoding the protein eosinophil-derived neurotoxin (EDN). Symptoms of Juvenile CACH Syndrome can include joint pain, swelling, and stiffness; skin rashes; fever; and anemia. Treatment typically involves medications to reduce inflammation and suppress the immune system.

The symptoms of CACH syndrome vary depending on the age of the individual. In general, the symptoms of CACH syndrome include:

• Delayed development
• Intellectual disability
• Poor muscle tone
• Seizures
• Abnormal facial features
• Abnormalities of the hands and feet
• Abnormalities of the eyes
• Abnormalities of the heart and other organs
• Abnormalities of the skeleton
• Abnormalities of the skin
• Abnormalities of the genitals
• Abnormalities of the urinary tract
• Abnormalities of the gastrointestinal tract
• Abnormalities of the immune system
• Abnormalities of the endocrine system
• Abnormalities of the nervous system
• Abnormalities of the blood and blood vessels

The exact cause of CACH syndrome is unknown. It is believed to be caused by a genetic mutation that affects the development of certain parts of the brain. It is also thought to be caused by environmental factors such as exposure to toxins or infections.

The treatment for Juvenile or adult CACH syndrome depends on the individual's symptoms and the severity of the condition. Treatment may include physical therapy, occupational therapy, speech therapy, medications, and surgery. Physical therapy can help improve strength, coordination, and balance. Occupational therapy can help improve daily living skills. Speech therapy can help improve communication and swallowing. Medications may be prescribed to help manage seizures, pain, and other symptoms. Surgery may be recommended to correct physical deformities or to improve mobility.

1. Family history of CACH syndrome
2. Genetic mutations in the EXT2 gene
3. Maternal diabetes
4. Low birth weight
5. Premature birth
6. Exposure to certain medications during pregnancy
7. Exposure to certain environmental toxins during pregnancy
8. Exposure to certain infections during pregnancy

At this time, there is no cure for CACH syndrome. Treatment focuses on managing the symptoms and complications associated with the condition. Medications may be prescribed to help manage seizures, muscle spasms, and other symptoms. Physical and occupational therapy may also be recommended to help improve mobility and strength.