Isolated neonatal sclerosing cholangitis (INSC) is a rare, progressive liver disease that affects newborns. It is characterized by inflammation and scarring of the bile ducts, which can lead to liver failure. Symptoms of INSC include jaundice, poor feeding, vomiting, and abdominal distention. Treatment typically involves a combination of medications, nutrition support, and, in some cases, liver transplantation.

The symptoms of Isolated neonatal sclerosing cholangitis (INSC) vary depending on the severity of the condition. Common symptoms include jaundice, poor growth, abdominal pain, fever, and dark urine. Other symptoms may include vomiting, diarrhea, and itching. In some cases, the condition may cause liver failure, which can lead to additional symptoms such as confusion, fatigue, and swelling in the abdomen.

Isolated neonatal sclerosing cholangitis (INSC) is a rare, progressive liver disease that affects newborns. The exact cause of INSC is unknown, but it is believed to be caused by a combination of genetic and environmental factors. Possible causes include:

- Genetic mutations that affect the development of the bile ducts

- Exposure to certain toxins or medications in utero

- Immune system abnormalities

- Infections, such as cytomegalovirus or Epstein-Barr virus

- Abnormalities in the structure of the bile ducts

- Metabolic disorders, such as cystic fibrosis or alpha-1 antitrypsin deficiency

The main treatment for Isolated neonatal sclerosing cholangitis is supportive care. This includes providing nutrition, hydration, and antibiotics to prevent infection. In some cases, a liver transplant may be necessary. Other treatments may include medications to reduce inflammation, antibiotics to treat infection, and medications to reduce bile acid levels. In some cases, surgery may be necessary to remove the affected bile ducts.

1. Prematurity
2. Low birth weight
3. Maternal diabetes
4. Maternal cholestasis
5. Maternal biliary tract infection
6. Maternal drug use
7. Maternal autoimmune disease
8. Maternal viral infection
9. Maternal nutritional deficiency
10. Genetic predisposition

At this time, there is no known cure for isolated neonatal sclerosing cholangitis. Treatment typically involves supportive care, such as nutritional support, antibiotics, and medications to reduce inflammation. In some cases, surgery may be necessary to remove the affected bile ducts.