Isolated congenitally uncorrected transposition of the great arteries (TGA) is a rare congenital heart defect in which the two main arteries of the heart, the aorta and the pulmonary artery, are switched in position. This means that the aorta, which normally carries oxygen-rich blood from the heart to the body, is connected to the right ventricle, and the pulmonary artery, which normally carries oxygen-poor blood from the heart to the lungs, is connected to the left ventricle. As a result, oxygen-poor blood is pumped to the body and oxygen-rich blood is pumped to the lungs, leading to a lack of oxygen in the body.

The most common symptoms of Isolated Congenitally Uncorrected Transposition of the Great Arteries (TGA) include:

- Cyanosis (blue skin color)
- Rapid breathing
- Poor feeding
- Poor weight gain
- Sweating
- Fatigue
- Rapid heart rate
- Heart murmur
- Poor circulation
- Low blood pressure
- Poor oxygen levels in the blood

The exact cause of isolated congenitally uncorrected transposition of the great arteries is unknown. However, some potential causes may include genetic mutations, environmental factors, and maternal health conditions.

1. Atrial switch procedure (Mustard or Senning procedure): This procedure involves switching the positions of the atria and the ventricles, allowing the oxygen-rich blood to flow to the body.

2. Arterial switch procedure (Jatene procedure): This procedure involves switching the positions of the aorta and the pulmonary artery, allowing the oxygen-rich blood to flow to the body.

3. Ventricular septal defect closure: This procedure involves closing the hole between the two ventricles, allowing the oxygen-rich blood to flow to the body.

4. Balloon atrial septostomy: This procedure involves creating a hole in the atrial septum, allowing the oxygen-rich blood to flow to the body.

5. Cardiac transplantation: This procedure involves replacing the

1. Maternal diabetes
2. Maternal rubella infection
3. Maternal use of certain medications, such as lithium, during pregnancy
4. Maternal alcohol use during pregnancy
5. Maternal smoking during pregnancy
6. Maternal age over 35
7. Family history of congenital heart defects
8. Low birth weight
9. Premature birth
10. Exposure to certain environmental toxins, such as lead or mercury

Yes, there is a cure for Isolated Congenitally Uncorrected Transposition of the Great Arteries (TGA). The most common treatment is a procedure called an arterial switch operation (ASO). This procedure involves switching the positions of the two main arteries in the heart, the aorta and the pulmonary artery. This procedure is usually done within the first few days of life. Other treatments may include medications to help manage symptoms, such as medications to help control the heart rate or to reduce the risk of blood clots.