Isolated congenital adermatoglyphia is a rare genetic disorder characterized by the absence of fingerprints. It is caused by a mutation in the SMARCAD1 gene, which is responsible for the development of the ridges on the skin that form fingerprints. People with this disorder have smooth, featureless fingertips and palms, and are unable to produce fingerprints.

The primary symptom of isolated congenital adermatoglyphia is the absence of fingerprints. Other symptoms may include:

-Smooth, hairless palms and soles
-Thin, sparse eyebrows
-Thin, sparse scalp hair
-Delayed tooth eruption
-Delayed bone age
-Mild facial dysmorphism
-Mild intellectual disability
-Hypoplastic nails
-Hypohidrosis (decreased sweating)
-Hypopigmentation of the skin

Isolated congenital adermatoglyphia is a rare genetic disorder caused by mutations in the SMARCAD1 gene. This gene is responsible for the production of a protein that helps to form the ridges on the skin of the fingers and toes. Mutations in this gene can cause the ridges to be absent, resulting in the characteristic features of this disorder. Other causes of Isolated congenital adermatoglyphia include environmental factors, such as exposure to certain chemicals or radiation, and genetic inheritance.

Unfortunately, there is no known treatment for Isolated congenital adermatoglyphia. However, there are some measures that can be taken to help manage the condition. These include:

1. Regularly moisturizing the skin to prevent dryness and cracking.

2. Wearing protective clothing and sunscreen to protect the skin from the sun.

3. Avoiding activities that may cause skin irritation or trauma.

4. Keeping the skin clean and dry to prevent infection.

5. Seeking medical advice if any signs of infection or irritation occur.

The exact cause of isolated congenital adermatoglyphia is unknown, but it is believed to be an inherited condition. Risk factors for isolated congenital adermatoglyphia include:

• Family history: Isolated congenital adermatoglyphia is believed to be an inherited condition, so having a family history of the condition increases the risk of developing it.

• Gender: Isolated congenital adermatoglyphia is more common in males than females.

• Age: Isolated congenital adermatoglyphia is usually diagnosed in childhood or adolescence.

At this time, there is no known cure or medication for isolated congenital adermatoglyphia. Treatment is focused on managing the symptoms and complications associated with the condition. This may include using moisturizers to help keep the skin hydrated, avoiding activities that may cause skin irritation, and using sunscreen to protect the skin from sun damage.