Infantile-onset periodic fever-panniculitis-dermatosis syndrome (IPFD) is a rare, inherited disorder characterized by recurrent episodes of fever, panniculitis (inflammation of the fat layer under the skin), and dermatosis (skin rash). It typically begins in infancy and is caused by mutations in the MEFV gene. Symptoms can include fever, rash, joint pain, abdominal pain, and eye inflammation. Treatment typically involves medications to reduce inflammation and fever.

The symptoms of Infantile-onset periodic fever-panniculitis-dermatosis syndrome (IPFD) include recurrent episodes of fever, panniculitis (Inflammation of the fat layer under the skin), and dermatosis (skin rash). Other symptoms may include abdominal pain, joint pain, and eye inflammation.

The exact cause of Infantile-onset periodic fever-panniculitis-dermatosis syndrome (IPFD) is unknown. However, it is believed to be an autoimmune disorder, meaning that the body’s immune system mistakenly attacks its own tissues. It is also thought to be caused by a genetic mutation, although the exact gene involved is still unknown.

The primary treatment for Infantile-onset periodic fever-panniculitis-dermatosis syndrome is the use of non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen to reduce inflammation and fever. Corticosteroids may also be used to reduce inflammation and suppress the immune system. In some cases, immunosuppressants such as methotrexate or azathioprine may be prescribed to reduce inflammation and prevent further episodes. In severe cases, intravenous immunoglobulin (IVIG) may be used to reduce inflammation and suppress the immune system.

1. Genetic predisposition: Infantile-onset periodic fever-panniculitis-dermatosis syndrome is caused by a mutation in the MEFV gene, which is inherited in an autosomal recessive pattern.

2. Age: Infantile-onset periodic fever-panniculitis-dermatosis syndrome typically presents in infancy or early childhood.

3. Gender: Infantile-onset periodic fever-panniculitis-dermatosis syndrome is more common in males than females.

4. Ethnicity: Infantile-onset periodic fever-panniculitis-dermatosis syndrome is more common in individuals of Mediterranean descent.

At this time, there is no known cure for Infantile-onset periodic fever-panniculitis-dermatosis syndrome. However, medications such as non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may be used to reduce inflammation and manage symptoms. Additionally, immunosuppressants may be used to reduce the severity of the condition.